PRIMARY STRUCTURE OF GAMMA-CARBOXYGLUTAMIC ACID-CONTAINING PROTEIN FROM BOVINE BONE

被引：259

作者：

PRICE, PA ^{[1
]}

POSER, JW ^{[1
]}

RAMAN, N ^{[1
]}

机构：

[1] UNIV CALIF SAN DIEGO, DEPT BIOL, LA JOLLA, CA 92093 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1976年 / 73卷 / 10期

关键词：

D O I：

10.1073/pnas.73.10.3374

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The amino-acid sequence of the .gamma.-carboxyglutamic acid-containing protein of bovine bone is presented. The sequence of 43 of the 49 residues was determined automatically on the intact protein and on a tryptic peptide. The remainder was determined by conventional procedures on tryptic and chymotryptic peptides. Residue 9 in the sequence was identified as 4-hydroxyproline. The protein contains 3 .gamma.-carboxyglutamic acid residues, which are located at positions 17, 21 and 24. The role of these unusual amino acids in the binding interaction between the protein and hydroxyapatite crystals is discussed.

引用

页码：3374 / 3375

页数：2

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