ENDOCRINE EFFECTS OF MASTURBATION IN MEN

The levels of pregnenolone, dehydroepiandrosterone (DHA), androstenedione, testosterone, dihydrotestosterone (DHT), estrone, estradiol, cortisol and luteinizing hormone (LH) were measured in the peripheral plasma of a group of young, apparently healthy males before and after masturbation. The same steroids were also determined in a control study, in which the psychological anticipation of masturbation was encouraged, but the physical act was not carried out. The plasma levels of all steroids were significantly increased after masturbation, whereas steroid levels remained unchanged in the control study. The most marked changes after masturbation were observed in pregnenolone and DHA levels. No alterations were observed in the plasma levels of LH. Before and after masturbation plasma levels of testosterone were significantly correlated to those of DHT and estradiol, but not to those of the other steroids studied. Cortisol levels were significantly correlated to those of pregnenolone, DHA, androstenedione and estrone. In the same subjects, the levels of pregnenolone, DHA, androstenedione, testosterone and DHT in seminal plasma were also estimated; they were all significantly correlated to the levels of the corresponding steroid in the systemic blood withdrawn before and after masturbation. As a practical consequence, the results indicate that whenever both blood and semen are analyzed, blood sampling must precede semen collection.