3' NON-CODING REGION SEQUENCES IN EUKARYOTIC MESSENGER-RNA

被引：2925

作者：

PROUDFOOT, NJ ^{[1
]}

BROWNLEE, GG ^{[1
]}

机构：

[1] MRC, MOLEC BIOL LAB, CAMBRIDGE CB2 2QH, ENGLAND

来源：

NATURE | 1976年 / 263卷 / 5574期

关键词：

D O I：

10.1038/263211a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The sequence A(adenine)-A-U(uracil)-A-A-A is present in 6 different purified messenger RNA molecules (specifically the .alpha.- and .beta.-globulin mRNA of rabbit and human, the immunoglobulin L chain mRNA of mouse (MOPC 21) and the ovalbumin mRNA of chicken) about 20 residues away from the 3''-terminal poly(A) sequence. In addition, a large selection of the 3'' non-coding regions of rabbit and human globin mRNA (both the .alpha.- and .beta.- globin mRNAs) are 85% homologous, demonstrating that this region is significantly conserved in evolution.

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页码：211 / 214

页数：4

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