EFFECTS OF MORPHINE SULFATE ON MEDIAL BULBORETICULAR RESPONSE TO PERIPHERALLY APPLIED NOXIOUS STIMULI

被引：24

作者：

SUN, CL ^{[1
]}

GATIPON, GB ^{[1
]}

机构：

[1] UNIV MISSISSIPPI, CTR MED, DEPT PHARMACOL & TOXICOL, JACKSON, MS 39216 USA

来源：

EXPERIMENTAL NEUROLOGY | 1976年 / 52卷 / 01期

关键词：

D O I：

10.1016/0014-4886(76)90195-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Response patterns of single neurons in the nucleus (n.) gigantocellularis were recorded extracellularly with glass microelectrodes in unanesthetized, functionally decerbarate cats immobilized with pancuronium. Electrical noxious stimulation of the saphenous nerve evoked 2 classes of responses in n. gigantocellularis neurons: excitatory and inhibitory. Morphine sulfate at analgesic doses of 1 to 2 mg/kg i.v. had a predominantly depressant action on the neuronal activity of both classes of neuronal responses from n. gigantocellularis. The depressant effects of morphine were reversed by naloxone (0.05-0.1 mg/kg i.v.). The depression of neuronal activity in the nucleus may partially explain the analgesic action.

引用

页码：1 / 12

页数：12

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