Diffusion tensor imaging in the human spinal cord: Development, limitations, and clinical applications

被引：26

作者：

Bosma, R.L. ^{[1
]}

Stroman, P.W. ^{[1
,2
]}

机构：

[1] Centre for Neuroscience Studies, Queen's University, Kingston, ON

[2] Departments of Diagnostic Radiology and Physics, Queen's University, Kingston, ON

来源：

Critical Reviews in Biomedical Engineering | 2012年 / 40卷 / 01期

关键词：

Amyotrophic lateral sclerosis; Diffusion tensor imaging; Human; Multiple sclerosis; Myelitis; Spinal cord; Spinal cord injury; Spinal cord tumors;

D O I：

10.1615/CritRevBiomedEng.v40.i1.10

中图分类号：

学科分类号：

摘要：

Diffusion tensor imaging (DTI) is currently the only non-invasive in vivo assessment of white matter tract integrity. Capitalizing on the diffusion properties of water within an axon, DTI enables the visualization of tissue structure at a microscopic scale. Furthermore, measurements of anisotropy and diffusivity enable the detection of subtle details of the effects of injury that cannot be detected using conventional magnetic resonance techniques. Recently, DTI has been applied to the spinal cord, and results have demonstrated it to be a valuable tool for assessing the extent of white matter damage in numerous spinal cord-related conditions including multiple sclerosis, spinal cord injury, amyotrophic lateral sclerosis, myelitis, and spinal cord tumors. The purpose of this review is to discuss the technical limitations of the imaging method within the spinal cord, review possible solutions, and highlight the current uses and the potential clinical application of this technique. © 2012 Begell House, Inc.

引用

页码：1 / 20

页数：19

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