Papain, a plant enzyme of biological importance: A review

被引：206

作者：

Amri, Ezekiel ^{[1
]}

Mamboya, Florence ^{[1
]}

机构：

[1] Department of Science and Laboratory Technology, Dares Salaam Institute of Technology (DIT), Dares Salaam

来源：

American Journal of Biochemistry and Biotechnology | 2012年 / 8卷 / 02期

关键词：

Cysteine protease; Hydrophobic; Papain; Proteolytic enzyme; Structure;

D O I：

10.3844/ajbbsp.2012.99.104

中图分类号：

O62 [有机化学]; TQ [化学工业];

学科分类号：

070303 [有机化学]; 081705 [工业催化];

摘要：

Papain is a plant proteolytic enzyme for the cysteine proteinase family cysteine protease enzyme in which enormous progress has been made to understand its functions. Papain is found naturally in papaya (Carica papaya L.) manufactured from the latex of raw papaya fruits. The enzyme is able to break down organic molecules made of amino acids, known as polypeptides and thus plays a crucial role in diverse biological processes in physiological and pathological states, drug designs, industrial uses such as meat tenderizers and pharmaceutical preparations. The unique structure of papain gives it the functionality that helps elucidate how proteolytic enzymes work and also makes it valuable for a variety of purposes. In the present review, its biological importance, properties and structural features that are important to an understanding of their biological function are presented. Its potential for production and market opportunities are also discussed. © 2012 Science Publication.

引用

页码：99 / 104

页数：5

共 40 条

[1]

Abu-Alruz K., Mazahreh A.S., Quasem J.M., Hejazin R.K., El-Qudah J.M., Effect of Proteases on Meltability and Stretchability of Nabulsi Cheese, Am. J. Agric. Biol. Sci, 4, pp. 173-178, (2009)

[2]

Beeley J.A., Yip H.K., Stevenson A.G., Chemochemical caries removal: A review of the techniques and latest developments, Br. Dent. J, 188, pp. 427-430, (2000)

[3]

Chamani J., Heshmati M., Rajabi O., Parivar K., Thermodynamic study of intermediate state of papain induced by n-alkyl sulfates at two different ph values:, A Spectroscopic Approach. Open Sur. Sci. J, 1, pp. 20-29, (2009)

[4]

Chukwuemeka N.O., Anthoni A.B., Antifungal effects of pawpaw seed extracts and papain on post harvest Carica papaya L. fruit rot, Afri. J. Agri. Res, 5, pp. 1531-1535, (2010)

[5]

Cohen L.W., Coghlan V.M., Dihel L.C., Cloning and sequencing of papain-encoding cDNA, Gene, 48, pp. 219-227, (1986)

[6]

Dietrich R.E., Oral proteolytic enzymes in the treatment of athletic injuries: A double-blind study, Pennsyl. Med. J, 68, pp. 35-37, (1965)

[7]

Edwin F., Jagannadham M.V., Single disulfide bond reduced papain exists in a compact intermediate state. Biochem. Biophys, Acta, 1479, pp. 69-82, (2000)

[8]

Edwin F., Sharma A., Jagannadham M.V., Single disulfide bond reduced papain exists in a compact intermediate state, Biochem. Biophys. Res. Commun, pp. 69-82, (2002)

[9]

Flindt M.L., Allergy to alpha-amylase and papain, Lancet, 1, pp. 1407-1408, (1979)

[10]

Gayosso-Garcia L.E., Yahia M.E., Martinez-Tellez M.A., Gonzalez-Aguilar A.G., Effect of maturity stage of papaya maradol on physiological and biochemical parameters, Am. J. Agric. Biol. Sci, 5, pp. 194-203, (2010)

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