脑白质损害与帕金森病认知功能障碍的研究进展

被引：27

作者：

唐红梅

张玉虎

王丽娟

机构：

[1] 广东省人民医院(广东省医学科学院)神经内科广东省神经科学研究所

来源：

中华老年心脑血管病杂志 | 2014年 / 16卷 / 03期

基金：

广东省科技计划; 广州市科技计划项目; 广东省自然科学基金;

关键词：

脑白质疏松症; 帕金森病; 认知障碍; 血脑屏障; 少突神经胶质;

D O I：

暂无

中图分类号：

R742.5 [震颤麻痹综合征];

学科分类号：

100204 [神经病学];

摘要：

<正>帕金森病(PD)是继阿尔茨海默病(AD)后人类第二大神经退行性疾病,由中脑黑质致密部多巴胺变性脱失引起,临床主要表现为运动症状和非运动症状,其中PD认知功能障碍近年来备受关注,包括PD轻度认知功能障碍和PD痴呆,随着病情的逐步进展,PD轻度认知功能障碍最终可发展为PD痴呆,给家庭和社会带来沉重负担,还增加PD患者的致残风险、死亡率和病死率[1-2]。PD患者从发病到进展为痴呆少则3～5年,多则20～30年,因此,对PD认知障碍患者

引用

页码：327 / 329

页数：3

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