丹参多酚酸治疗缺血性脑卒中的疗效及对血清神经元特异性烯醇化酶和新蝶呤水平的影响

被引：9

作者：

梁慧敏

孙娇

李玉珠

高洋

贺维亚

机构：

[1] 河南大学淮河医院神经内科

来源：

医学综述 | 2018年 / 24卷 / 22期

关键词：

缺血性脑卒中; 丹参多酚酸; 血清神经元特异性烯醇化酶; 新蝶呤;

D O I：

暂无

中图分类号：

R743.3 [急性脑血管疾病（中风）];

学科分类号：

100204 [神经病学];

摘要：

目的探究丹参多酚酸治疗缺血性脑卒中的疗效及对血清神经元特异性烯醇化酶(NSE)和新蝶呤水平的影响。方法选择2015年2月至2017年2月河南大学淮河医院治疗的发病时间24 h内的98例缺血性脑卒中患者为研究对象,依据随机数字法分为试验组和对照组,各49例。对照组给予常规治疗,试验组在常规治疗的基础上进行丹参多酚酸静脉滴注。比较观察两组患者的临床疗效,治疗前后美国国立卫生院卒中神经功能缺损评分量表(NIHSS)评分及血清中NSE和新蝶呤水平。结果试验组总有效率高于对照组[91. 84%(45/49)比75. 51%(37/49)](P <0. 05)。治疗后,试验组患者NIHSS评分低于对照组[(8. 9±3. 4)分比(12. 5±2. 2)分](P <0. 01)。治疗后,试验组血清NSE和新蝶呤水平低于对照组[(18. 2±7. 1) mg/L比(22. 5±7. 5) mg/L、(12. 7±6. 9) nmol/L比(15. 3±7. 1) nmol/L](P <0. 05)。结论丹参多酚酸治疗缺血性脑卒中的临床疗效确切,可促进神经功能恢复,降低患者血清NSE和新蝶呤水平。

引用

页码：4569 / 4572+4576 +4576

页数：5

共 23 条

[1]

Salvianolic acids enhance cerebral angiogenesis and neurological recovery by activating JAK2/STAT3 signaling pathway after ischemic stroke in mice [J].

Li, Yaoru ;

Zhang, Xiangjian ;

Cui, Lili ;

Chen, Rong ;

Zhang, Ye ;

Zhang, Cong ;

Zhu, Xingyuan ;

He, Tingting ;

Shen, Zuyuan ;

Dong, Lipeng ;

Zhao, Jingru ;

Wen, Ya ;

Zheng, Xiufen ;

Li, Pan .

JOURNAL OF NEUROCHEMISTRY, 2017, 143 (01) :87-99

[2]

Neuroprotective effect of salvianolic acid B against cerebral ischemic injury in rats via the CD40/NF-κB pathway associated with suppression of platelets activation and neuroinflammation.[J].Shixin Xu;Aiqin Zhong;Huining Ma;Dan Li;Yue Hu;Yingzhi Xu;Junping Zhang.Brain Research.2017,

[3]

Salvianolic acid A alleviates ischemic brain injury through the inhibition of inflammation and apoptosis and the promotion of neurogenesis in mice.[J].Mei-Yin Chien;Cheng-Hung Chuang;Chang-Ming Chern;Kou-Tong Liou;Der-Zen Liu;Yu-Chang Hou;Yuh-Chiang Shen.Free Radical Biology and Medicine.2016,

[4]

Salvianolic Acid B Ameliorates Cerebral Ischemia/Reperfusion Injury Through Inhibiting TLR4/MyD88 Signaling Pathway [J].

Wang, Yujue ;

Chen, Guang ;

Yu, Xiangdong ;

Li, Yunchao ;

Zhang, Li ;

He, Zongze ;

Zhang, Nannan ;

Yang, Xiuping ;

Zhao, Yansheng ;

Li, Na ;

Qiu, Hong .

INFLAMMATION, 2016, 39 (04) :1503-1513

[5]

Serum neuron specific enolase could predict subclinical brain damage and the subsequent occurrence of brain related vascular events during follow up in essential hypertension.[J].Alina González-Quevedo;Sergio González-García;Zenaida Hernández-Díaz;Otman Fernández Concepción;Luis Quevedo Sotolongo;Marisol Peña-Sánchez;Benjamín Márquez Rosales;Rosaralis Santiesteban Freixas;Isabel Fernández-Almirall;María Caridad Menéndez-Sainz;Rebeca Fernández-Carriera.Journal of the Neurological Sciences.2016,

[6]

Serum neuron specific enolase level as a predictor of prognosis in acute ischemic stroke patients after intravenous thrombolysis [J].

Lu, Kaili ;

Xu, Xiaofeng ;

Cui, Shasha ;

Wang, Feng ;

Zhang, Bin ;

Zhao, Yuwu .

JOURNAL OF THE NEUROLOGICAL SCIENCES, 2015, 359 (1-2) :202-206

[7]

Salvianolic acid B attenuates apoptosis and inflammation via SIRT1 activation in experimental stroke rats.[J].Hongdi Lv;Ling Wang;Jinchang Shen;Shaojun Hao;Aimin Ming;Xidong Wang;Feng Su;Zhengchen Zhang.Brain Research Bulletin.2015,

[8]

Salvianolic Acid B Down-regulates Matrix Metalloproteinase-9 Activity and Expression in Tumor Necrosis Factor-α-induced Human Coronary Artery Endothelial Cells [J].