钙和维生素D对高脂饮食诱发的小鼠乳腺上皮增生的影响

被引：1

作者：

薛乐勋

袁保梅

王建民

许培人

王建人

机构：

[1] 河南医科大学医学实验中心!郑州，

[2] 河南中医学院生理教研室

来源：

肿瘤防治研究 | 1998年 / 06期

关键词：

乳腺; 上皮细胞增生; 钙; 维生素D;

D O I：

暂无

中图分类号：

R730.231 [肿瘤病因学、发生学];

学科分类号：

100214 ;

摘要：

本研究目的是观察饮食中添加钙和维生素D对高脂饮食诱发的小鼠乳腺上皮细胞增生的影响。将四周龄小鼠随机分成三组，分别给予对照AIN－76A饲料，高脂低钙低维生素D饲料（试验饲料Ⅰ）和高脂加钙加维生素D饲料（试验饲料Ⅱ）。饲养九周后终止试验，小鼠植入渗透泵灌注溴脱氧尿苷（Brdu）72小时。结果显示试验饲料Ⅰ组的小鼠乳腺终末小导管上皮细胞Brdu标记指数与对照饲料组比较明显升高（P＜0．05）。而试验饲料Ⅱ组的BrdU标记指数与对照组相似（P＞0．05）。本实验研究发现进一步证明，高脂饮食能诱发小鼠乳腺小导管上皮细胞的增生，同时也提示饮食中添加钙和维生素D有助于预防高脂饮食的这种不良作用。

引用

页码：451 / 454

页数：4

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