快速老化型小鼠SAMP8在阿尔茨海默病研究中的应用

被引:8
作者
董靖德
王小姗
机构
[1] 南京医科大学附属脑科医院老年神经科
关键词
SAMP8小鼠; 阿尔茨海默病; 氧化应激; 发病机制;
D O I
暂无
中图分类号
R749.16 [];
学科分类号
摘要
作为衰老模型,SAMP8小鼠显示了许多发生在阿尔茨海默病早期的特性,如行为紊乱、记忆力下降、氧化应激反应增加、β淀粉样蛋白沉积和tau蛋白磷酸化。因此,SAMP8小鼠是研究早期阿尔茨海默病的极佳模型。通过回顾SAMP8小鼠的行为学、神经化学及神经病理特性,研究SAMP8小鼠在阿尔茨海默病发病机制中的价值。
引用
收藏
页码:804 / 806
页数:3
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