帕金森病步态障碍的研究进展

被引：20

作者：

郭炜杭

许二赫

机构：

[1] 首都医科大学宣武医院神经内科

来源：

中风与神经疾病杂志 | 2020年 / 37卷 / 01期

基金：

国家重点研发计划;

关键词：

帕金森病; 步态障碍; 多巴胺能通路; 胆碱能通路;

D O I：

10.19845/j.cnki.zfysjjbzz.2020.01.020

中图分类号：

R742.5 [震颤麻痹综合征];

学科分类号：

100204 [神经病学];

摘要：

<正>1背景帕金森病(Parkinson's disease,PD)作为较为常见的中枢神经系统退行性疾病,除了运动迟缓、静止性震颤、肌张力增高和姿势平衡障碍外,还存在着步态障碍,严重影响了PD患者的生活质量和独立生活能力。帕金森病步态障碍的发病机制目前仍不是完全明确,现有的研究主要集中在PD患者的运动自动化能力下降、多巴胺能通路受损和胆碱能通路受损,现有的治疗主要包括药物治疗、手术治疗和物理治疗。本文将主要围绕帕金森病步态障碍的发病机制进行详细综

引用

页码：76 / 79

页数：4

共 30 条

[1]

CSF β-amyloid42 and risk of freezing of gait in early Parkinson disease.[J].Ryul Kim;Joongyub Lee;Han-Joon Kim;Aryun Kim;Mihee Jang;Beomseok Jeon;Un Jung Kang.Neurology.2018,

[2]

Freezing of gait: Promising avenues for future treatment.[J].Moran Gilat;Ana Lígia Silva de Lima;Bastiaan R. Bloem;James M. Shine;Jorik Nonnekes;Simon J.G. Lewis.Parkinsonism and Related Disorders.2018,

[3]

Relationships between gait and emotion in Parkinson's disease: A narrative review.[J].Laura Avanzino;Giovanna Lagravinese;Giovanni Abbruzzese;Elisa Pelosin.Gait & Posture.2018,

[4]

What is the therapeutic mechanism of pedunculopontine nucleus stimulation in Parkinson's disease?.[J].Wesley Thevathasan;Elena Moro.Neurobiology of Disease.2019,

[5]

Dysfunctional Limbic Circuitry Underlying Freezing of Gait in Parkinson’s Disease.[J].Moran Gilat;Kaylena A. Ehgoetz Martens;Oscar Miranda-Domínguez;Ishu Arpan;James M. Shine;Martina Mancini;Damien A. Fair;Simon J.G. Lewis;Fay B. Horak.Neuroscience.2018,

[6]

Direct and indirect effects of attention and visual function on gait impairment in Parkinson's disease: influence of task and turning [J].

Stuart, Samuel ;

Galna, Brook ;

Delicato, Louise S. ;

Lord, Sue ;

Rochester, Lynn .

EUROPEAN JOURNAL OF NEUROSCIENCE, 2017, 46 (01) :1703-1716

[7]

Association of Gait Characteristics and Depression in Patients with Parkinson’s Disease Assessed in Goal-Directed Locomotion Task.[J].Péter Kincses;Norbert Kovács;Kázmér Karádi;ádám Feldmann;Krisztina Dorn;Zsuzsanna Aschermann;Sámuel Komoly;Tibor Szolcsányi;árpád Csathó;János Kállai;Ivan Bodis-Wollner.Parkinson’s Disease.2017,

[8]

Subthalamic nucleus stimulation and gait in Parkinson’s Disease: a not always fruitful relationship.[J].Giovanni Cossu;Massimiliano Pau.Gait & Posture.2017,

[9]

Unmasking levodopa resistance in Parkinson's disease [J].