o/w型、w/o型葛根素口服微乳的制备及质量评价

被引：21

作者：

刘霞

向大雄

机构：

[1] 中南大学药学院

来源：

中南药学 | 2007年 / 05期

关键词：

葛根素; 微乳; 质量评价; 伪三元相图;

D O I：

暂无

中图分类号：

TQ461 [中草药制剂的生产];

学科分类号：

091003 [林草生态工程学];

摘要：

目的研制o/w型、w/o型葛根素口服微乳制剂并进行质量评价。方法通过相图研究进行处方筛选,并考察最大载药量。对制备的o/w型、w/o型微乳的性质进行考察。结果得到空白微乳的最终处方(重量比)为:o/w型微乳:RH∶1,2-丙二醇∶EO∶水=12.6∶6.3∶2.1∶79.0;w/o型微乳:PC∶无水乙醇∶EO∶水=45∶22.5∶27.5∶5。葛根素含量均为30 mg.mL-1,平均粒径分别为23.4和46.2 nm。结论o/w型、w/o型微乳均能显著提高葛根素溶解度,且制备简单,质量稳定。

引用

页码：451 / 455

页数：5

共 11 条

[1]

Development of self-microemulsifying drug delivery systems (SMEDDS) for oral bioavailability enhancement of simvastatin in beagle dogs.[J].Bok Ki Kang;Jin Soo Lee;Se Kang Chon;Sang Young Jeong;Soon Hong Yuk;Gilson Khang;Hai Bang Lee;Sun Hang Cho.International Journal of Pharmaceutics.2004, 1

[2]

Microemulsion formulation for enhanced absorption of poorly soluble drugs.[J].Kohsaku Kawakami;Takayoshi Yoshikawa;Yasushi Moroto;Eri Kanaoka;Koji Takahashi;Yoshitaka Nishihara;Kazuyoshi Masuda.Journal of Controlled Release.2002, 1

[3]

Comparison of total oral bioavailability and the lymphatic transport of halofantrine from three different unsaturated triglycerides in lymph-cannulated conscious rats [J].

Holm, R ;

Müllertz, A ;

Christensen, E ;

Hoy, CE ;

Kristensen, HG .

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2001, 14 (04) :331-337

[4]

Preparation and evaluation of biphenyl dimethyl dicarboxylate microemulsions for oral delivery.[J].Chong-Kook Kim;Yeon-Ju Cho;Zhong-Gao Gao.Journal of Controlled Release.2001, 1

[5]

Lipid-based delivery systems for improving the bioavailability and lymphatic transport of a poorly water-soluble LTB4 inhibitor [J].