癫痫发作间期血清中IL-1β和IL-6水平分析研究

被引：14

作者：

井晓荣

靳俊功

李焕发

董珊

武昊

王晓庆

马伟

孟强

张华

机构：

[1] 第四军医大学唐都医院神经外科,全军功能性神经外科研究所,功能性脑疾病研究所

来源：

立体定向和功能性神经外科杂志 | 2014年 / 27卷 / 02期

关键词：

癫痫; 白细胞介素1; 白细胞介素6; ELISA法;

D O I：

暂无

中图分类号：

R742.1 [癫痫];

学科分类号：

100204 [神经病学];

摘要：

目的癫痫发作间期外周血清中白细胞介素-1β(IL-1β)和白细胞介素-6(IL-6)的含量分析及意义。方法 ELISA法分别测定53例癫痫患者发作间期及30例正常人外周血清中IL-1β和IL-6含量,对癫痫组和正常组之间,同时对癫痫患者组内进行性别、年龄、病程、发作频度、间期脑电的正异常、起源区域局限性(局限和广泛)进行比较,实验数据(含量)结果用x±s表示,两样本采用秩和检验。结果癫痫组与正常组之间IL-1β和IL-6外周血液血清中含量的差异均有统计学意义;癫痫组不同发作频度之间IL-6血清中含量的差异有统计学意义,不同发作频度对于IL-1β含量无统计学意义;癫痫组不同性别、年龄、病程、间期脑电(正常和异常)、起源区域(局限和广泛)血清中IL-1β和IL-6含量的差异均无统计学意义。结论发作间期IL-1β和IL-6在外周血清中的含量因癫痫而发生变化,癫痫患者的免疫系统处于活化状态,证明两种细胞因子参与癫痫活动,血清中IL-6含量与发作频度有关。

引用

页码：73 / 78

页数：6

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