中国汉族人群结核易感相关基因多态性研究

被引：14

作者：

邵凌云

翁心华

胡忠义

靳安佳

张文宏

机构：

[1] 复旦大学附属华山医院传染科

[2] 上海市肺科医院检验科

[3] 复旦大学附属华山医院传染科上海

[4] 上海

来源：

中华传染病杂志 | 2004年 / 05期

关键词：

NRAMP1基因; 多态性,限制性片段长度; 结核肺; 聚合酶链反应;

D O I：

暂无

中图分类号：

R521 [肺结核];

学科分类号：

1002 ; 100201 ;

摘要：

目的通过病例对照研究明确结核感染与NRAMP1基因多态性的关系。方法选择127例活动性肺结核患者,均为汉族,平均年龄52.5岁,另选与民族匹配的58例健康对照者。对上述入选者通过聚合酶链反应限制性片段长度多态性(PCRRFLP)分析对NRAMP1基因多态性——内含子4(INT4)、D543N进行检测。结果两种NRAMP1基因多态性均与痰涂片阳性的结核显著相关。在结核患者中INT4与D543N的杂合子形式为对结核易感的多态性。NRAMP1的不同基因多态性的协同作用导致了对结核的易感性。结论NRAMP1基因多态性可以影响中国汉族人群对结核的易感性。

引用

页码：13 / 16

页数：4

共 11 条

[1]

The Bcg host-resistance gene. Buu N,Sanchez F,Schurr E. Clinical Infectious Diseases . 2000

[2]

Natural resistance to infection with intracellular parasites: isolation of a candidate for Bcg. Vidal SM,Malo D,Vogan K,et al. Cell . 1993

[3]

The growing burden of tuberculosis: global trends and interactions with the HIV epidemic. Corbett EL,Watt CJ,Walker N,et al. Archives of Internal Medicine . 2003

[4]

NRAMP1 polymorphisms,susceptibility and clinical features of tuberculosis. Abe T,Iinuma Y,Ando M,et al. Journal of Infection . 2003

[5]

Racial differences in susceptibility to infection by Mycobacterium tuberculosis. Stead WW,Senner JW,Reddick WT,et al. The New England Journal of Medicine . 1990

[6]

Identification of polymorphisms and sequence variations in the human homologue of the mouse natural resistance-associated macrophage protein gene. Liu J,Fujiwara TM,Buu NT,et al. The American Journal of Human Genetics . 1995

[7]

Human natural resistance associated macrophage protein: cDNA cloning, chromosomal mapping, genomic organization, and tissue-specific expression. Cellier M,Govoni G,Vidal S,et al. The Journal of Experimental Medicine . 1994

[8]

Complete nucleotide sequence and genomic structure of the human NRAMP1 gene region on chromosome region 2q35. Marquet S,Lepage P,Hudson TJ,et al. Mammalian Genome . 2000

[9]

Factors predicting persistent sputum smear positivity among pulmonary tuberculosis patients 2 months after treatment. Singla R,Osman MM,Khan N,et al. International Journal of Tuberculosis and Lung Disease . 2003

[10]

Variations in the NRAMP1 gene and susceptibility to tuberculosis in West Africans. Bellamy R,Ruwende C,Corrah T,et al. The New England Journal of Medicine . 1998

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