TLR4信号通路与炎性反应

被引:148
作者
陈洁
姜虹
机构
[1] 上海交通大学医学院附属第九人民医院麻醉科
关键词
Toll样受体; Toll样受体4; 脂多糖; CD14; 炎性反应;
D O I
暂无
中图分类号
R392 [医学免疫学];
学科分类号
100108 [医学免疫学];
摘要
Toll样受体(TLR)是一类天然免疫受体,最早发现其与果蝇胚胎背、腹侧的发育有关。随着研究的深入,哺乳动物体内也发现有类似同源性受体,并统一称TLR家族。TLR的分布十分广泛,可以识别某些病原体或其产物所共有的特定结构。TLR4是介导内毒素/脂多糖应答的主要受体,而TLR4/CD14信号通路是介导内毒素诱导的炎性反应的重要通路。营养性肥胖、动脉粥样硬化、心肌梗死、哮喘等所引起的非细菌性炎性反应也与TLR4相关。本文就TLR4信号通路与炎性反应的研究进展进行综述。
引用
收藏
页码:2902 / 2904
页数:3
相关论文
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