抗偏头痛新药洛美利嗪

被引:7
作者
郑莉
刘国卿
机构
[1] 中国药科大学药理教研室
[2] 中国药科大学药理教研室 南京
[3] 南京
关键词
洛美利嗪; 抗偏头痛药; 钙通道拮抗剂;
D O I
暂无
中图分类号
R971 [神经系统药物];
学科分类号
1007 ;
摘要
洛美利嗪 ,一种新型二苯哌嗪类衍生物 ,目前临床上主要治疗偏头痛和丛集性头痛。洛美利嗪与氟桂利嗪等钙通道拮抗剂不同 ,具有钙通道和钠通道双重阻断作用 ,洛美利嗪在nmol·L-1至 μmol·L-1水平 ,在多部位具有生物活性 ,包括血管和神经元钙通道、钠通道、α1肾上腺素受体和 5 HT2 受体 ,以及自由基清除作用。本文综述了洛美利嗪的药理作用、药动学与临床疗效等。
引用
收藏
页码:178 / 181
页数:4
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