普拉克索治疗帕金森病合并抑郁症的临床观察

被引:11
作者
王国权
黄流清
赵忠新
机构
[1] 第二军医大学附属长征医院神经内科
关键词
帕金森病; 抑郁症; 普拉克索;
D O I
暂无
中图分类号
R742.5 [震颤麻痹综合征];
学科分类号
1002 ;
摘要
目的评价普拉克索对帕金森病合并抑郁症患者的临床疗效及安全性。方法本院确诊为原发帕金森病患者共30例予普拉克索治疗3个月,在治疗前后进行自评抑郁量表(SDS)、统一帕金森病评定量表(UPDRS)和简易精神状态检查(MMSE)量表评分。结果 PD患者普拉克索治疗后SDS、UPDRS评分较治疗前显著降低,而MMSE量表评分治疗前后比较差异不明显。SDS量表中哭泣、思维混乱、思考困难、不满足感改善最明显,且普拉克索副反应轻微。结论普拉克索治疗PD的部分非运动症状及抑郁症安全且具有一定的效果。
引用
收藏
页码:231 / 233
页数:3
相关论文
共 7 条
[1]   帕金森病患者亚抑郁的研究 [J].
郑瑾 ;
乔娴 ;
孙圣刚 .
卒中与神经疾病, 2010, 17 (01) :36-38
[2]  
Dyskinesias and Treatment with Pramipexole in Patients with Parkinson's Disease[J] . John C. P. Piedad,Andrea E. Cavanna,Gilberto Fisone.Parkinson’s Disease . 2012
[3]  
Potential mechanisms underlying anxiety and depression in Parkinson's disease: Consequences of l -DOPA treatment[J] . Karen L. Eskow Jaunarajs,Mariana Angoa-Perez,Donald M. Kuhn,Christopher Bishop.Neuroscience and Biobehavioral Reviews . 2010 (3)
[4]  
Reward pathways in Parkinson's disease: Clinical and theoretical implications[J] . LorysCastelli.Psychiatry and Clinical Neurosciences . 2008 (2)
[5]  
Characteristics of depression in Parkinson's disease: Evaluating with Zung's Self-Rating Depression Scale[J] . Fumio Kanda,Kenichi Oishi,Kenji Sekiguchi,Atsushi Kuga,Hiroshi Kobessho,Toshihiko Shirafuji,Masatsugu Higuchi,Hiroyuki Ishihara.Parkinsonism and Related Disorders . 2007 (1)
[6]  
Current Pharmacotherapeutic Treatment Options in Parkinson’s Disease[J] . Michael Rezak.Disease-a-Month . 2007 (4)
[7]  
Non-motor symptoms of Parkinson's disease: diagnosis and management[J] . K Ray Chaudhuri,Daniel G Healy,Anthony HV Schapira.Lancet Neurology . 2006 (3)