干细胞因子及其受体在卵泡早期发育中的作用

被引：4

作者：

严杰 ^{[1
]}

乔杰 ^{[1
]}

机构：

[1] 北京大学第三医院妇产科生殖医学中心

来源：

中华生殖与避孕杂志 | 2008年 / 12期

关键词：

干细胞因子; c-Kit; 卵母细胞; 颗粒细胞; 细胞因子;

D O I：

暂无

中图分类号：

R714.8 [];

学科分类号：

100211 ;

摘要：

目前认为卵泡早期发育是非促性腺激素依赖性过程。此期干细胞因子是启动原始卵泡发育、过渡为初级卵泡的必需因子, 与受体c-Kit结合后激活c-Kit下游3-磷酸肌醇激酶等信号通路, 调控卵母细胞生长、颗粒细胞和卵泡膜细胞分化、增殖及激素合成。干细胞因子与骨形态发生蛋白15、生长分化因子9等细胞因子相互影响, 受促性腺激素调控, 共同参与卵母细胞-颗粒细胞对话。

引用

页码：739 / 744

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