磷酸二酯酶抑制剂与学习记忆相关信号转导通路研究进展

被引：8

作者：

王闯 ^{[1
]}

程玉芳 ^{[1
]}

张汉霆 ^{[1
,2
]}

徐江平 ^{[1
]}

机构：

[1] 南方医科大学药学院药理学系

[2] Dept of Behavioral Medicine and Psychiatry,West Virginia University Health Sciences Center

来源：

中国药理学通报 | 2009年 / 07期

基金：

广东省自然科学基金;

关键词：

cAMP; cGMP; 信号转导通路; 学习记忆; 神经退行性变疾病; 靶点;

D O I：

暂无

中图分类号：

R96 [药理学];

学科分类号：

100602 ; 100706 ;

摘要：

大量的研究表明,环磷酸腺苷反应元件结合蛋白(cAMP response element binding protein,CREB)直接或间接激活相关基因转录,进而表达c-fos、c-jun、BDNF等,在神经元应激损伤后的再生、存活及修复以及学习记忆等方面发挥重要作用。磷酸二酯酶可以水解环磷酸腺苷(cyclic AMP,cAMP)及环磷酸鸟苷(cyclic GMP,cGMP),进而影响其下游信号转导,发挥对CREB的调节作用。该文从磷酸二酯酶抑制剂与学习记忆相关信号通路的关系及在学习记忆障碍中发挥的作用予以综述,并由该通路入手对发现治疗神经退行性变疾病药物作用新靶点的可能性予以展望。

引用

页码：844 / 847

页数：4

共 7 条

[1] 磷酸二酯酶4研究进展 [J].

孙超渊 ;

张莉 ;

程克棣 ;

杜冠华 ;

朱平 .

中国药理学通报, 2006, (10) :1161-1167

[2] LONG-TERM ADMINISTRATION OF GREEN TEA CATECHINS PREVENTS AGE-RELATED SPATIAL LEARNING AND MEMORY DECLINE IN C57BL/6 J MICE BY REGULATING HIPPOCAMPAL CYCLIC AMP-RESPONSE ELEMENT BINDING PROTEIN SIGNALING CASCADE [J].

Li, Q. ;

Zhao, H. F. ;

Zhang, Z. F. ;

Liu, Z. G. ;

Pei, X. R. ;

Wang, J. B. ;

Cai, M. Y. ;

Li, Y. .

NEUROSCIENCE, 2009, 159 (04) :1208-1215

[3]

The effect of selective inhibition of cyclic GMP hydrolyzing phosphodiesterases 2 and 5 on learning and memory processes and nitric oxide synthase activity in brain during aging[J] . Brain Research . 2008

[4] NMDA-induced neuroprotection in hippocampal neurons is mediated through the protein kinase A and CREB (cAMP-response element-binding protein) pathway [J].

Valera, Elvira ;

Sanchez-Martin, Francisco J. ;

Ferrer-Montiel, Antonio V. ;

Messeguer, Angel ;

Merino, Jaime M. .

NEUROCHEMISTRY INTERNATIONAL, 2008, 53 (05) :148-154

[5] The PDE4 inhibitor rolipram reverses object memory impairment induced by acute tryptophan depletion in the rat [J].

Rutten, K. ;

Lieben, C. ;

Smits, L. ;

Blokland, A. .

PSYCHOPHARMACOLOGY, 2007, 192 (02) :275-282

[6] Effects of the novel PDE4 inhibitors MEM1018 and MEM1091 on memory in the radial-arm maze and inhibitory avoidance tests in rats [J].

Zhang, HT ;

Huang, Y ;

Suvarna, NU ;

Deng, CJ ;

Crissman, AM ;

Hopper, AT ;

De Vivo, M ;

Rose, GM ;

O'Donnell, JM .

PSYCHOPHARMACOLOGY, 2005, 179 (03) :613-619

[7]

Effects of two selective phosphodiesterase type 5 inhibitors, sildenafil and vardenafil, on object recognition memory and hippocampal cyclic GMP levels in the rat[J] . Neuroscience . 2002 (2)

← 1 →