乌司他丁对肾脏缺血-再灌注损伤的保护作用

被引：13

作者：

贾辉

刘志勇

机构：

[1] 江苏省肿瘤医院

[2] 东南大学医学院附属中大医院南京

[3] 南京

来源：

江苏医药 | 2005年 / 03期

关键词：

乌司他丁; 缺血-再灌注损伤; 肾功能;

D O I：

10.19460/j.cnki.0253-3685.2005.03.015

中图分类号：

R96 [药理学];

学科分类号：

100602 ; 100706 ;

摘要：

目的　探讨乌司他丁对肾脏缺血-再灌注损伤的保护作用。方法　取30只雄性新西兰家兔,随机分成三组:对照组(C组)、抑肽酶组(A组)和乌司他丁组(U组),建立兔在体肾脏缺血再灌注损伤模型。观察三组再灌注后4、24、48 h三个时点血尿素氮(BUN)、血肌酐(Cr)和尿N 乙酰- β- D -氨基葡萄糖苷酶(NAG)的变化。结果　再灌注 24、48 h, U组 BUN值、Cr 值比 C组和 A组低(P<0 .05)。再灌注4 h,U组NAG值最低,A组其次,C组最高(P<0 .05);再灌注48 h,U组和A组NAG值比C组低(P<0 .05),但U组与A组之间无明显差异性。结论　乌司他丁能减轻肾脏缺血再灌注损伤。

引用

页码：194 / 196

页数：3

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