RISK信号通路在心肌预处理及后处理中的作用

被引：16

作者：

方军 ^{[1
,2
]}

吴黎明 ^{[1
,3
]}

陈良龙 ^{[1
,2
]}

机构：

[1] 福建医科大学附属协和医院心内科

[2] 福建省冠心病研究所

[3] 福建省老年医学研究所

来源：

中国病理生理杂志 | 2009年 / 25卷 / 10期

关键词：

PI3K-Akt; ERK1/2; 预处理; 后处理; 心肌再灌注损伤;

D O I：

暂无

中图分类号：

R541 [心脏疾病];

学科分类号：

100201 [内科学];

摘要：

The anti-apoptotic pro-survival kinase signaling cascades,phosphatidylinositol-3-OH kinase(PI3K)-Akt and p42/p44 extra-cellular signal-regulated protein kinases(ERK 1/2),which have been termed the reperfusion injury salvage kinase(RISK)pathway,are involved in cellular survival.In myocardial ischemic preconditioning,pharmacological preconditioning,ischemic postconditioning and pharmacological postconditioning,the activation of these kinase cascades at the time of reperfusion has been demonstrated to confer cardioprotection against reperfusion-induced injury.Targeting the RISK signaling pathway may provide a novel strategy to salvaging viable myocardium and limiting infarct size during myocardial ischemia-reperfusion.

引用

页码：2062 / 2067

页数：6

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