白花前胡丙素的结构修饰研究

被引：9

作者：

吴献礼

孔令义

闵知大

机构：

[1] 中国药科大学天然药物化学教研室,中国药科大学天然药物化学教研室,中国药科大学天然药物化学教研室江苏南京,江苏南京,江苏南京

来源：

药学学报 | 2002年 / 07期

关键词：

白花前胡丙素; 结构修饰; 钙离子拮抗活性;

D O I：

10.16438/j.0513-4870.2002.07.007

中图分类号：

R284 [中药化学];

学科分类号：

摘要：

目的　对白花前胡丙素 [(+) praeruptorinA]进行结构修饰 ,寻找活性化合物。方法　首先从白花前胡(Peucedanumpraeruptorum)根中分离得到白花前胡丙素 ,从白花前胡丙素出发 ,用碱水解及各种酰化反应 ,半合成各种结构修饰产物。结果　得到 18个 (2～ 19)凯林内酯类化合物 ,通过IR ,1 HNMR和MS等方法确定其结构。结论　其中 14个 (5～ 18)为新化合物 ,这些新化合物均有不同程度的钙离子拮抗活性 ,但作用强度均较白花前胡丙素弱。

引用

页码：527 / 534

页数：8

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