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高压氧治疗对急性脑梗死患者血清C反应蛋白和白细胞介素-6含量的影响及疗效观察

被引：7
作者：
吴杨
王水平
程晋成
刘英
杨世泉
夏添
王轶群
余本松
机构：
[1] 解放军第八二医院超声科
[2] 解放军第一二三医院高压氧神经内科
来源：
中华航海医学与高气压医学杂志 | 2013年 / 01期
关键词：
高压氧; 脑梗死; C反应蛋白; 白细胞介素-6; 美国国立卫生研究院卒中量表; Barthel指数;
D O I：
暂无
中图分类号：
R743.3 [急性脑血管疾病（中风）];
学科分类号：
1002 ;
摘要：
目的观察高压氧(HBO)治疗对急性脑梗死患者血清C反应蛋白(CRP)、白细胞介素-6(IL-6)的影响及其治疗效果。方法经患者知情同意,并签署知情同意书后,将83例急性脑梗死患者按完全随机法分为对照组(43例)和HBO组(40例),另取40名健康体检者作为正常对照(正常组)。对照组给予必要的脱水、阿托伐他汀、阿司匹林、奥扎格雷、胞二磷胆碱等常规治疗;HBO组在行常规治疗的同时加用HBO治疗1个疗程。治疗前后行血清CRP、IL-6含量检测及美国国立卫生研究院卒中量表(NIHSS)及生活能力Barthel指数(BI)评分,CRP、IL-6分别采用免疫比浊法和ELISA检测,梗死后6个月随访时再次行BI评分。结果治疗前2组患者血清CRP和IL-6含量差异无统计学意义(P>0.05),NIHSS评分分别为23.4±5.28、24.8±4.92,BI评分分别为30.7±10.14、31.1±11.45,差异均无统计学意义(P>0.05);治疗后2组CRP和IL-6含量较治疗前均明显降低(P<0.05),NIHISS评分分别为16.30±5.57、12.70±5.92,较治疗前均明显下降(P<0.05),BI评分分别为44.20±12.18、52.40±13.36,较治疗前均明显升高(P<0.05);与对照组比较,HBO组CRP和IL-6含量降低及NIHSS评分下降、BI评分升高均更为明显(P<0.05);6个月后随访时2组BI评分分别为76.30±18.49、85.40±19.27,与治疗后比较均有明显升高(P<0.05),HBO组较对照组升高更为明显(P<0.05)。结论 HBO治疗可显著降低急性脑梗死患者血清CRP和IL-6含量,减轻脑组织炎性反应,促进神经功能的恢复,从而提高临床疗效。
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