冠心病患者凝血酶激活的纤溶抑制物与纤维蛋白原关系分析

被引:2
作者
许延路 [1 ]
高辉 [1 ]
李继福 [2 ]
徐从高 [2 ]
机构
[1] 山东省血栓病防治工程技术研究中心
[2] 山东大学齐鲁医院
关键词
冠心病; 凝血酶激活的纤溶抑制物; 纤维蛋白原;
D O I
暂无
中图分类号
R541.4 [冠状动脉(粥样)硬化性心脏病(冠心病)];
学科分类号
1002 ; 100201 ;
摘要
目的探讨冠心病患者血浆中凝血酶激活的纤溶抑制物(TAFI)与纤维蛋白原(Fbg)的关系。方法分别应用ELISA法、发色底物法测定40例冠状动脉造影正常者和60例经冠状动脉造影证实的(冠心病CAD)患者血浆中TAFI:Ag、TAFI:A及Fbg的含量。结果CAD患者血浆中TAFI:Ag(95±34%)、TAFI:A(29.2±11.2g/ml)、Fbg(5.20±2.41g/L)均明显高于冠脉造影正常者(P<0.001)。结论CAD患者血浆中TAFI:Ag和TAFI:A均显著增高,抑制了Fbg的降解,导致纤溶活性降低。
引用
收藏
页码:211 / 212
页数:2
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