乌司他丁保护百草枯中毒大鼠肺免受损伤的作用

被引：19

作者：

陈达

张洪颖

贾浩

朱杰

机构：

[1] 中国医科大学附属第四医院急诊科

来源：

中国病理生理杂志 | 2015年 / 31卷 / 01期

关键词：

乌司他丁; 急性肺损伤; 百草枯; 丝裂原活化蛋白激酶; 金属蛋白酶组织抑制物; 基质金属蛋白酶;

D O I：

暂无

中图分类号：

R595.4 [药物中毒];

学科分类号：

1002 ; 100201 ;

摘要：

目的:探讨乌司他丁保护百草枯中毒大鼠肺免受损伤的作用及其机制。方法:Wistar大鼠108只,随机分为对照组、百草枯组和乌司他丁组。百草枯组和乌司他丁组给予百草枯灌胃染毒,对照组给予无菌生理盐水灌胃,乌司他丁组同时给予乌司他丁治疗。1、3、7、14、21、28 d测血清中的MDA、SOD、IL-6、IL-10和TNF-α水平,以及肺组织中的p38 MAPK、MMP-2和TIMP-1表达水平。结果:1、3、7 d百草枯组和乌司他丁组的SOD均较对照组下降(P<0.01),乌司他丁组SOD明显高于百草枯组(P<0.05)。1、3、7 d百草枯组和乌司他丁组的MDA、IL-6、IL-10及TNF-α均较对照组增高(P<0.01),乌司他丁组各指标明显低于百草枯组(P<0.05)。1、3、7、14、21、28d百草枯组和乌司他丁组肺组织中的p38 MAPK及TIMP-1均较对照组增高(P<0.01),乌司他丁组各指标明显低于百草枯组(P<0.05)。1、3、7、14、21 d百草枯组和乌司他丁组肺组织中的MMP-2均较对照组增高(P<0.01),乌司他丁组MMP-2明显低于百草枯组(P<0.05)。结论:乌司他丁通过抑制p38 MAPK信号通路及抗炎、抗氧化作用保护百草枯中毒大鼠肺免受损伤的作用。

引用

页码：166 / 171

页数：6

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