OPG/RANKL/RANK：联系骨骼系统与免疫系统的纽带

被引：21

作者：

张云云

梁新月

闫建设

机构：

[1] 上海大学生命科学学院

来源：

自然杂志 | 2020年 / 42卷 / 02期

关键词：

OPG/RANKL/RANK; 骨骼系统; 骨代谢; 破骨细胞; 成骨细胞; 免疫系统;

D O I：

暂无

中图分类号：

R392 [医学免疫学];

学科分类号：

100108 [医学免疫学];

摘要：

机体的骨组织细胞和免疫细胞相互影响,使骨骼系统与免疫系统间建立起诸多联系。NF-k B受体活化因子配体不仅调控骨骼和免疫器官的发育,而且在骨骼的自身免疫性疾病中起重要作用。文章简要介绍骨骼系统和免疫系统的结构和生物学功能,阐述骨代谢与免疫系统之间的相互调控作用,重点论述骨保护素/核因子k B受体活化因子配体/核因子k B受体活化因子(OPG/RANKL/RANK)系统作为纽带联系骨骼系统与免疫系统的功能。

引用

页码：102 / 107

页数：6

共 11 条

[1]

Osteocyte-Intrinsic TGF-β Signaling Regulates Bone Quality through Perilacunar/Canalicular Remodeling [J].

Dole, Neha S. ;

Mazur, Courtney M. ;

Acevedo, Claire ;

Lopez, Justin P. ;

Monteiro, David A. ;

Fowler, Tristan W. ;

Gludovatz, Bernd ;

Walsh, Flynn ;

Regan, Jenna N. ;

Messina, Sara ;

Evans, Daniel S. ;

Lang, Thomas F. ;

Zhang, Bin ;

Ritchie, Robert O. ;

Mohammad, Khalid S. ;

Alliston, Tamara .

CELL REPORTS, 2017, 21 (09) :2585-2596

[2]

RANKL (Receptor Activator of NFκB Ligand) Produced by Osteocytes Is Required for the Increase in B Cells and Bone Loss Caused by Estrogen Deficiency in Mice [J].

Fujiwara, Yuko ;

Piemontese, Marilina ;

Liu, Yu ;

Thostenson, Jeff D. ;

Xiong, Jinhu ;

O'Brien, Charles A. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2016, 291 (48) :24838-24850

[3]

ICOS-Ligand Triggering Impairs Osteoclast Differentiation and Function In Vitro and In Vivo [J].

Gigliotti, Casimiro L. ;

Boggio, Elena ;

Clemente, Nausicaa ;

Shivakumar, Yogesh ;

Toth, Erika ;

Sblattero, Daniele ;

D'Amelio, Patrizia ;

Isaia, Giovanni C. ;

Dianzani, Chiara ;

Yagi, Junji ;

Rojo, Jose M. ;

Chiocchetti, Annalisa ;

Boldorini, Renzo ;

Bosetti, Michela ;

Dianzani, Umberto .

JOURNAL OF IMMUNOLOGY, 2016, 197 (10) :3905-3916

[4]

Systemic neutralization of TGF‐β attenuates osteoarthritis.[J].Liang Xie;Francis Tintani;Xiao Wang;Fengfeng Li;Gehua Zhen;Tao Qiu;Mei Wan;Janet Crane;Qianming Chen;Xu Cao.Annals of the New York Academy of Sciences.2016, 1

[5]

Production of RANKL by Memory B Cells: A Link Between B Cells and Bone Erosion in Rheumatoid Arthritis [J].

Meednu, Nida ;

Zhang, Hengwei ;

Owen, Teresa ;

Sun, Wen ;

Wang, Victor ;

Cistrone, Christopher ;

Rangel-Moreno, Javier ;

Xing, Lianping ;

Anolik, Jennifer H. .

ARTHRITIS & RHEUMATOLOGY, 2016, 68 (04) :805-816

[6]

Osteocytes Regulate Primary Lymphoid Organs and Fat Metabolism [J].

Sato, Mari ;

Asada, Noboru ;

Kawano, Yuko ;

Wakahashi, Kanako ;

Minagawa, Kentaro ;

Kawano, Hiroki ;

Sada, Akiko ;

Ikeda, Kyoji ;

Matsui, Toshimitsu ;

Katayama, Yoshio .

CELL METABOLISM, 2013, 18 (05) :749-758

[7]

Anti IL-17A therapy inhibits bone loss in TNF-α-mediated murine arthritis by modulation of the T-cell balance [J].

Zwerina, Karin ;

Koenders, Marije ;

Hueber, Axel ;

Marijnissen, Renoud J. ;

Baum, Wolfgang ;

Heiland, Gisela Ruiz ;

Zaiss, Mario ;

Mclnnes, Iain ;

Joosten, Leo ;

van den Berg, Wim ;

Zwerina, Jochen ;

Schett, Georg .

EUROPEAN JOURNAL OF IMMUNOLOGY, 2012, 42 (02) :413-423

[8]

IFN-γ directly inhibits TNF-α-induced osteoclastogenesis in vitro and in vivo and induces apoptosis mediated by Fas/Fas ligand interactions.[J].Haruka Kohara;Hideki Kitaura;Yuji Fujimura;Masako Yoshimatsu;Yukiko Morita;Toshiko Eguchi;Ritsuko Masuyama;Noriaki Yoshida.Immunology Letters.2011, 1

[9]

The role of the immune system in the pathophysiology of osteoporosis.[J].Jackie A.Clowes;B. LawrenceRiggs;SundeepKhosla.Immunological Reviews.2005, 1

[10]

Inflammatory bone destruction and osteoimmunology [J].

Takayanagi, H .

JOURNAL OF PERIODONTAL RESEARCH, 2005, 40 (04) :287-293

← 1 2 →