胰岛素样生长因子1与脑缺血

被引:9
作者
刘宗超
王慕一
机构
[1] 中国医科大学附属第一临床学院神经内科
关键词
胰岛素样生长因子1; 脑缺血; 神经营养因子; 脑保护;
D O I
暂无
中图分类号
R743 [脑血管疾病];
学科分类号
1002 ;
摘要
胰岛素样生长因子 1(IGF 1)是一种多肽。脑缺血后 ,在缺血脑组织内的表达增加 ,其功能相关结合蛋白表达亦增加。脑缺血再灌注后 ,经侧脑室给予IGF 1可明显减轻缺血区脑组织的损伤程度。体外培养也显示 ,IGF 1对神经细胞有营养保护作用。有实验证明 ,IGF 1能通过血脑屏障。这些都表明 ,IGF 1有可能作为一种脑保护剂用于脑缺血的治疗。
引用
收藏
页码:162 / 164
页数:3
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