绝经后女性骨关节炎和骨质疏松患者血清性激素结合蛋白水平比较分析

被引：9

作者：

李海东

杨越华

李波

戴力扬

蒋雷生

机构：

[1] 上海交通大学医学院附属新华医院成人骨科

来源：

上海交通大学学报(医学版) | 2011年 / 31卷 / 08期

关键词：

骨关节炎; 骨质疏松; 雌激素; 性激素结合蛋白;

D O I：

暂无

中图分类号：

R580 []; R684.3 [关节炎];

学科分类号：

100220 [骨科学];

摘要：

目的分析绝经后女性骨关节炎(OA)和骨质疏松(OP)患者血清雌二醇、性激素结合蛋白(SHBG)水平差异及其各自与股骨近端、腰椎骨密度及血清骨保护素(OPG)之间的相关性,探讨SHBG在这两种疾病中的作用机制。方法选取绝经后女性OA和OP患者各60例,用放射免疫法和ELISA法分别检测血清雌二醇、SHBG和OPG等。游离雌二醇指数(FEI)用血清雌二醇与SHBG的摩尔比率表示。结果 OA组患者的体质量、体质量指数、骨密度明显高于OP组患者。两组患者血清雌二醇水平差异无统计学意义(P=0.124),但OP组患者血清SHBG及OPG水平均高于OA组患者[SHBG:(74.98±8.90)nmol/L和(66.38±9.74)nmol/L,P<0.01;OPG:(6.94±1.18)pmol/L和(4.67±1.28)pmol/L,P<0.01],而FEI为OA组高于OP组(0.75±0.31和0.63±0.27,P<0.05)。两组患者血清SHBG和股骨近端、腰椎骨密度之间均有明显负相关性,而FEI与两个部位骨密度间均呈正相关。结论绝经后女性OA与OP患者血清SHBG水平的差异可能是引起活性雌激素水平差异、导致骨密度和骨微结构不同的重要因素。

引用

页码：1134 / 1139

页数：6

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