八肽胆囊收缩素对大鼠心功能的影响及受体机制(英文)

被引：3

作者：

赵晓云

凌亦凌

孟爱宏

单宝恩

张君岚

机构：

[1] 河北医科大学病理生理学教研室,河北医科大学病理生理学教研室,河北医科大学病理生理学教研室,河北医科大学第四医院科研中心,河北医科大学病理生理学教研室石家庄,石家庄,石家庄,石家庄

来源：

生理学报 | 2002年 / 03期

关键词：

胆囊收缩素; 心功能; 受体;

D O I：

暂无

中图分类号：

R363 [病理生理学];

学科分类号：

100104 ;

摘要：

为探讨八肽胆囊收缩素 (CCK 8)对麻醉大鼠心功能的影响及受体机制 ,实验监测了左心室收缩压(LVP)、左心室收缩与舒张期内压变化的最大速率 (±LVdp/dtmax)、心率 (HR)和平均动脉压 (MAP)。结果如下 :小剂量CCK 8(0 4 μg/kg)可引起心动过速 ,MAP、LVP和±LVdp/dtmax轻度上升 ;中剂量CCK 8(4 μg/kg)和大剂量CCK 8(4 0 μg/kg)可引起心动过缓 ,MAP、LVP和±LVdp/dtmax显著增加 ;应用CCK 受体 (CCK R)拮抗剂丙谷胺 (1 0mg/kg)抑制以上变化 ;由逆转录聚合酶链反应 (RT PCR)检测到心肌组织有CCK A受体 (CCK AR)和CCK B受体 (CCK BR)mRNA表达。以上结果提示 :CCK 8可激活心肌组织的CCK R ,引起剂量依赖性的心功能增加和心率改变。

引用

页码：239 / 243

页数：5

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