微栓子与不稳定性心绞痛症状的关系探讨

被引:9
作者
石怀银
韦立新
李小鹰
孙璐
郭爱桃
机构
[1] 解放军总医院病理科
[2] 解放军总医院南楼心内科
关键词
心绞痛; 心肌梗塞; 微栓子;
D O I
暂无
中图分类号
R541.4 [冠状动脉(粥样)硬化性心脏病(冠心病)];
学科分类号
摘要
目的 探讨微栓子在不稳定性心绞痛发生中的作用。方法  10例心脏标本取自急性心肌梗死死亡病例 ,生前有典型不稳定性心绞痛症状。心脏固定后完整剥离冠状动脉 ,冠状动脉经脱钙后每隔 3~ 4mm连续取材 ,从心尖至房室交界按冠状面每隔 4~ 5mm切成大组织片 ,然后将组织片全部取材。冠状动脉和心肌组织块经常规HE染色后显微镜下观察血栓和心肌内小血管微栓子。同时对 10例年龄相当的稳定性心绞痛死亡患者的心脏做对照研究 ,研究方法同上。结果  10例不稳定性心绞痛病例中 9例心肌内小血管中检出微栓子 ;而稳定性心绞痛组仅 1例查见微栓子。两组比较差异具显著性 (P <0 0 1)。不稳定性心绞痛与稳定性心绞痛组冠状动脉内血栓检出率之比为 9∶1,差异有显著性 (P <0 0 1)。结论 不稳定性心绞痛患者心肌内微栓子明显多于稳定性心绞痛。微栓子可能是不稳定性心绞痛发生的原因之一
引用
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页码:8 / 10
页数:3
相关论文
共 7 条
[1]  
Plaque pathology and coronary thrombosis in the pathogenesis of acute coronary syndromes. Zhou J,Chew M,Ravn HB,et al. Scandinavian Journal of Clinical and Laboratory Investigation . 1999
[2]  
Why is recurrent myocardial ischaemia a predictor of adverse outcome in unstable angina?An observational study of myocardial ischaemia and its relation to coronary anatomy. Patel DJ,Gomma AH,Knight CJ,et al. European Heart Journal . 2001
[3]  
Plaque fissuring: the cause of acute myocardial infarction, sudden ischaemic death and unstable angina. Davies MJ,Thomas AC. British Heart Journal . 1985
[4]  
Angiographic features at ischemia- or infarct-related sites in patients with acute coronary syndrome: morphology changing in a relatively short time. Koiwaya Y,Nagoshi T,Doi H,et al. Journal of Cardiology . 2001
[5]  
Angiographic features at ischemia or infarct-related sites in patients with acute coronary syndrome: morphology changing in a relatively short time. Koiwaya Y,Nagoshi T,Doi H,et al. Journal of Cardiology . 2001
[6]  
Atherothrombosis as a systemic disease. Drouet L. Cerebrovascular Diseases . 2002
[7]  
The symptomatic carotid plaque. Golledge J,Greenhalgh RM,Davies AH. Stroke . 2000