脂蛋白(a)受体与LDL受体关系的研究

被引:4
作者
李白桦
刘德文
沃兴德
机构
[1] 山西中医学院生化教研室
[2] 山西医科大学生化教研室
[3] 浙江中医学院分子医学研究所
关键词
脂蛋白(a)受体; LDL受体/apoB-100受体; 配体(基); 脂蛋白(a)单特异抗体; Westernblotting;
D O I
暂无
中图分类号
Q51 [蛋白质];
学科分类号
071010 ; 081704 ;
摘要
本文用蛋白质免疫印迹方法(Westernblotting)研究了猕猴肝细胞膜上脂蛋白(a)受体和LDL受体。探讨当前尚有争议的脂蛋白(a)与LDL的代谢是经同一受体途径还是不同受体途径。实验结果显示:脂蛋白(a)受体(~300kD)与LDL受体(~185kD)是分子量不同的两种受体。该结果揭示脂蛋白(a)有其自身的代谢途径。
引用
收藏
页码:27 / 31
页数:5
相关论文
共 8 条
[1]  
Isolation, characterization, and uptake in human fibroblasts of an apo(a)-free lipoprotein obtained on reduction of lipoprotein(a). Armstrong V W,Walli A K,Seidel D. Journal of Lipid Research . 1985
[2]  
The low density lipoprotein receptor is not required for normal catabolism of Lp(a) in humans. Rader D J,Mann W A,Cain W. The Journal of Clinical Investigation . 1995
[3]  
cDNA sequence of human apolipoprotein(a) is homologous to plasminogen. Mclean J W,Tomlinson J E,Kuang W J. Nature . 1987
[4]  
Overexpression of human low density lipoprotein receptors leads to accelerated catabolism of Lp(a) lipoprotein in transgenic mice. Hofmann S L,Baton D L,Brown M L. The Journal of Clinical Investigation . 1990
[5]  
Cholesterol loading of macrophages leads to marked enhancement of native lipoprotein(a) and apoprotein(a) internalization and degradation. Bottalico L A,Keesler G A,Fless G M. Journal of Biological Chemistry . 1993
[6]  
Binding of Lp ( a ) to the low density lipoprotein receptor of human fibroblasts. Havekes L,Vermecr B J,Brugman T. FEBS Letters . 1981
[7]  
Uptake of Lp( a) lipoprotein by cultured fibroblasts. Floren C H,Albers J J,Bierman E L. Biochemical and Biophysical Research Communications . 1981
[8]  
The interaction of Lp( a) with normal and LDL receptor-deficient human skin fibroblasts. Kostner G M,Grillhofer H. Chemistry and Physics of Lipids . 1994