抗乙型病毒性肝炎新药——阿德福韦酯

被引:246
作者
茅益民
曾民德
机构
[1] 上海第二医科大学附属仁济医院上海市消化疾病研究所,上海第二医科大学附属仁济医院上海市消化疾病研究所,
关键词
病毒性肝炎,乙型; 治疗学; 阿德福韦酯;
D O I
暂无
中图分类号
R96 [药理学];
学科分类号
100602 ; 100706 ;
摘要
<正> 阿德福韦酯是由美国Gilead Science公司开发的新型核苷类抗乙型病毒性肝炎药物,已在国外进行了Ⅱ、Ⅲ期临床试验。国外的临床研究资料表明,阿德福韦能有效地抑制HBV DNA的复制,使HBV DNA滴度迅速降低,而且在出现拉米夫定耐药的患者中阿德福韦能继续有效地抑制变异株。我国药品监督管理局于2000年12月批准该药在中国进行临床试验,目前,Ⅰ期临床试验已结束,Ⅱ期临床试验也已在2002年12月正式启动。
引用
收藏
页码:63 / 65
页数:3
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