外周血循环滤泡辅助性T细胞及IL-21在银屑病中的表达及意义

被引：15

作者：

薛国辉 ^{[1
]}

华琳 ^{[1
]}

刘晓峰 ^{[1
]}

陈雪礼 ^{[1
]}

赵汝霖 ^{[2
,3
]}

周南进 ^{[2
,3
]}

机构：

[1] 九江市第一人民医院/南昌大学附属九江医院检验科

[2] 江西省医学科学院分子医学研究所

[3] 南昌大学免疫与生物治疗研究所

来源：

中国免疫学杂志 | 2016年 / 32卷 / 11期

关键词：

银屑病; 滤泡辅助T细胞; 白介素-21; Th17;

D O I：

暂无

中图分类号：

R758.63 [牛皮癣（银屑病）]; R446.6 [免疫学检验];

学科分类号：

100208 [临床检验诊断学]; 100227 [皮肤病学];

摘要：

目的:探讨外周血循环滤泡辅助性T细胞（Follicular helper T cells,Tfh）及相关细胞因子IL-21在银屑病患者中的表达水平及其与疾病活动度的关系。方法:收集38例银屑病患者及32例健康对照者,流式细胞术检测外周血循环CD4+CXCR5+Tfh和CD4+CXCR5+ICOS+Tfh细胞比例以及Th17细胞比例;ELISA检测血清IL-21浓度;分析这些指标间及与银屑病疾病活动度评分PASI间的相关性。结果:与健康对照者相比,银屑病患者外周血循环CD4+CXCR5+Tfh和CD4+CXCR5+ICOS+Tfh细胞比例更高,血清IL-21浓度和Th17细胞比例亦显著高于对照组（P<0.05）;IL-21浓度与CD4+CXCR5+Tfh和CD4+CXCR5+ICOS+Tfh细胞比例均显著正相关,而与Th17细胞比例间无显著相关性（P>0.05）;且CD4+CXCR5+ICOS+Tfh细胞比例和血清IL-21与银屑病疾病活动度PASI评分显著正相关,而CD4+CXCR5+Tfh则与之无显著相关性（P>0.05）。结论:银屑病患者外周血循环Tfh比例、IL-21浓度上调与银屑病患者疾病活动度密切相关,提示Tfh可能参与银屑病的发生发展过程,这一效应可能是通过分泌高水平IL-21实现;IL-21浓度与Tfh细胞比例相关,而与Th17细胞比例无相关性提示银屑病患者IL-21可能主要由Tfh细胞分泌。

引用

页码：1645 / 1648+1652 +1652

页数：5

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