质谱联用技术在生物样品分析中的应用

被引:30
作者
赵龙山 [1 ]
李清 [1 ]
郭超伟 [2 ]
陈晓辉 [1 ]
毕开顺 [1 ]
机构
[1] 沈阳药科大学药学院
[2] 《中国新药杂志》有限公司
关键词
质谱; 生物样品分析; 药物代谢动力学; 生物等效性; 毒代动力学; 代谢组学;
D O I
暂无
中图分类号
R96 [药理学];
学科分类号
100706 [药理学];
摘要
质谱分析具有分析范围广、灵敏度高、样品用量少、分析速度快、重复性好、操作简易、损耗低、分离与鉴定可同时进行等优点,已广泛应用于环境科学、能源化工、生物医药等领域。本文综述了近3年国内外关于质谱联用技术在生物样品分析中应用的文献,并着重介绍了质谱技术在药物代谢动力学和生物等效性、毒代动力学、药代动力学-药效学、群体药代动力学、药物及代谢物结构确证与裂解规律和代谢组学中的应用,以期为生物样品分析的进一步发展提供参考。
引用
收藏
页码:158 / 162
页数:5
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