骨生长肽与骨质疏松症

被引：3

作者：

彭英芳

机构：

[1] 首都师范大学生物系北京

来源：

关键词：

骨生长肽; 功能; 骨质疏松症;

D O I：

暂无

中图分类号：

R58 [内分泌腺疾病及代谢病];

学科分类号：

摘要：

骨生长肽(OGP)是一个由14个氨基酸组成的多肽,广泛存在于人和哺乳动物血清中。现已发现OGP有两个重要功能:促进成骨细胞和成纤维细胞的生长及促进造血作用。目前,动物实验已表明OGP可用于骨质疏松症的治疗。

引用

页码：90 / 91+97 +97

页数：3

共 13 条

[1] Structureandfunctionalcharac-terizationofOGPfromhumanserum:inedtitywithratandmousehomologs. GreenbergZ,ChorevM,MuhlradA,etal. JClinEndocrinolMetabolism . 1995
[2] IsolationofOGPfromOBMC3T3anddemonstrationofOGPBP. GreenbergZ,GavishH,MuhlradA,etal. JCellularBiochemistry . 1997
[3] Regeneratingbonemarrowpro-duceapotentgrowth-promotingacticitytoosteogeniccells. BabI,GazitD,MuhlradA,etal. The Journal of Endocrinology . 1988
[4] BiosynthesisofOGPviaalterna-tivetranslationalinitiationatAUG85ofhistoneH4mRNA. BabI,SmithE,GavishH,etal. Journal of Biochemistry . 1999
[5] Roleofpolypeptidesinthetreatmentanddiagnosisofosteoporosis. KunduB,KhareSK,SinghG. Peptides . 1999
[6] HistoneH4-relatedosteogenicgrowthpeptide:anovelcirculationgstimulatorofosteoblasticactivity. BabI,ChorevP,MuhlradA,etal. EMBO Journal . 1992
[7] Humanalpha-macroglobulinisanosteogenicgrowthpeptidebindingprotein. GavishH,BabI,TartakovskyA,etal. Biochemistry . 1997
[8] Structure-bioactivityofC-termi-nalpentapeptideofosgeogenicgrowthpeptide[OGP(10-14)]. ChenYC,BabI,MansurN,etal. JPep-tideRes . 2000
[9] Thehistomorphometryofboneinprima-ryhyperparathyroidism:preservationofcancellousbonestructure. ParisienM,SilverbergSJ. JClinEndocrinolMetabolism . 1990
[10] Regulatoryroleofosteogenicgrowthpeptideinproliferation,osteogenesis,andhemopoiesis. BabI. ClinicalOrthopaedicsandRelatedRe-search . 1995