白细胞介素18(IL-18)的研究进展

被引：15

作者：

刘亚普

机构：

[1] 河南省濮阳市人民医院

来源：

中国医药指南 | 2008年 / 13期

关键词：

D O I：

暂无

中图分类号：

R392.12 [免疫细胞生物学];

学科分类号：

100108 [医学免疫学];

摘要：

<正>白细胞介素18(Interleukin-18,IL-18)最初名为干扰素诱生因子(Interferon gamma inducing factor,IGIF)或白细胞介素1γ,现已了解它有重要的免疫调节和保护功能。它可诱生IFN-γ及Fasl表达,增强IL-2和GM-CSF的活性,可与许多细胞因子相互作用,参与了自身免疫性疾病,变态反应性疾病的发生,在许多疾病

引用

页码：67 / 70

页数：4

共 14 条

[1]

IL-18 mRNA expression up-regulation in Crohn''s disease..Pizarro TT;Michie MH;Bentz M;.J Immuno.1999, 01

[2]

Association between adult-onset Still''s disease and interleukin-18 gene polymorphism..Sugiura T;Kawaguchi Y;Horigai M;.Genes Immun.2002, 07

[3]

No association between interleukin-18 gene polymorphisms and haplotypes in Dutch sarcoidosis patients [J].

Janssen, R ;

Grutters, JC ;

Ruven, HJT ;

Zanen, P ;

Sato, H ;

Welsh, KI ;

du Bois, RM ;

van den Bosch, JMM .

TISSUE ANTIGENS, 2004, 63 (06) :578-583

[4]

Single-nucleotide polymorphisms of the interleukin-18 gene promoter region in rheumatoid arthritis patients: protective effect of AA genotype [J].

Sivalingam, SP ;

Yoon, KH ;

Koh, DR ;

Fong, KY .

TISSUE ANTIGENS, 2003, 62 (06) :498-504

[5]

IL-18 promoter polymorphisms correlate with the development of post-injury sepsis [J].

Stassen, NA ;

Breit, CM ;

Norfleet, LA ;

Polk, HC .

SURGERY, 2003, 134 (02) :351-356

[6]

Association of single nucleotide polymorphisms in the IL-18 gene with sarcoidosis in a Japanese population [J].

Takada, T ;

Suzuki, E ;

Morohashi, K ;

Gejyo, F .

TISSUE ANTIGENS, 2002, 60 (01) :36-42

[7]

Interleukin-18 is a unique cytokine that stimulates both Th1 and Th2 responses depending on its cytokine milieu [J].

Nakanishi, K ;

Yoshimoto, T ;

Tsutsui, H ;

Okamura, H .

CYTOKINE & GROWTH FACTOR REVIEWS, 2001, 12 (01) :53-72

[8]

Cloning and mutation analysis of the human IL-18 promoter: a possible role of polymorphisms in expression regulation.[J].Vilmantas Giedraitis;Bing He;Wen-Xin Huang;Jan Hillert.Journal of Neuroimmunology.2001, 1

[9]

Defective NK Cell Activity and Th1 Response in IL-18–Deficient Mice.[J].Kiyoshi Takeda;Hiroko Tsutsui;Tomohiro Yoshimoto;Osamu Adachi;Nobuaki Yoshida;Tadamitsu Kishimoto;Haruki Okamura;Kenji Nakanishi;Shizuo Akira.Immunity.1998, 3

[10]

Interferon-γ-Inducing Factor; a Novel Cytokine; Enhances Fas Ligand-Mediated Cytotoxicity of Murine T Helper 1 Cells.[J].Tao Dao;Kunihiro Ohashi;Tohru Kayano;Masashi Kurimoto;Haruki Okamura.Cellular Immunology.1996, 2

← 1 2 →