心力衰竭中能量代谢重构研究进展

被引：48

作者：

陈游洲

袁建松

乔树宾

机构：

[1] 北京协和医学院中国医学科学院阜外心血管病医院冠心病诊治中心

来源：

中国循环杂志 | 2014年 / 29卷 / 04期

关键词：

心力衰竭; 代谢重构;

D O I：

暂无

中图分类号：

R541.6 [血液循环衰竭];

学科分类号：

100201 [内科学];

摘要：

应用神经体液拮抗剂可以明显降低心力衰竭(心衰)的发病率和死亡率,但预后仍较差。重新评估心衰时的生物学变化,可能有助于找出新的治疗方法。心衰中心肌能量缺乏和底物利用障碍促进心肌重构的病程进展,即心肌的能量"代谢重构"。能量代谢重构是心衰治疗的新靶点,但目前对调节心肌能量代谢的通路和机制认识不足,缺少针对代谢相关的酶及蛋白调节的药物。对相关通路的认识可能有助于发现心衰新的治疗方法,本文将对心衰中心肌代谢重构的特点及心肌能量代谢的治疗方法进行综述,为心衰治疗提供新思路。

引用

页码：306 / 308

页数：3

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