新型口服降糖药DPP-4抑制剂:从胰岛α细胞看2型糖尿病治疗的新进展

被引:22
作者
洪天配
机构
[1] 北京大学第三医院内分泌科
关键词
胰岛α细胞; 胰升糖素; GLP-1; DPP-4抑制剂; 糖尿病,2型;
D O I
暂无
中图分类号
R587.1 [糖尿病];
学科分类号
100201 [内科学];
摘要
胰岛α细胞分泌的胰升糖素是升高血糖的重要激素之一。GLP-1参与机体血糖的稳态调节,其机制包括抑制胰岛α细胞的胰升糖素分泌。然而,体内的GLP-1极易被DPP-4所降解。DPP-4抑制剂可选择性抑制DPP-4的活性,减少内源性GLP-1的降解,可作为治疗T2DM的一类新型药物。
引用
收藏
页码:558 / 560
页数:3
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