亚甲兰临床应用进展

被引：11

作者：

陈斯琴

王英伟

机构：

[1] 上海交通大学医学院新华医院麻醉科

来源：

上海交通大学学报(医学版) | 2008年 / 02期

关键词：

亚甲蓝; 血流动力学; 血压;

D O I：

暂无

中图分类号：

R96 [药理学];

学科分类号：

100602 ; 100706 ;

摘要：

亚甲蓝作为鸟苷酸环化酶的抑制剂,能减少细胞内环鸟嘌呤核苷单磷酸盐(cGMP)生成,从而防止过量一氧化氮介导的血管平滑肌舒张作用,升高平均动脉压和体循环阻力,减少机体对血管收缩剂的需求,并且增加心肌收缩力,改善组织灌注,降低血浆乳酸的水平。文章就亚甲蓝稳定血流动力学的作用机制及其临床应用进行综述。

引用

页码：206 / 208

页数：3

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