老年人亚甲基四氢叶酸还原酶、蛋氨酸合成酶基因多态性及同型半胱氨酸水平与冠心病的关系

被引：7

作者：

季福绥

范海荣

孙福成

何青

王抒

许锋

夏永静

机构：

[1] 卫生部北京医院心内科

[2] 卫生部北京医院老年医学研究所生化室

来源：

中华老年医学杂志 | 2004年 / 06期

关键词：

冠状动脉疾病; 半胱氨酸; 亚甲基四氢叶酸脱氢酶;

D O I：

暂无

中图分类号：

R541.4 [冠状动脉（粥样）硬化性心脏病（冠心病）];

学科分类号：

1002 ; 100201 ;

摘要：

目的　探讨老年人同型半胱氨酸 (Hcy)水平与冠心病的关系 ,并对亚甲基四氢叶酸还原酶 (MTHFR)A12 98C基因多态性、蛋氨酸合成酶 (MS)A2 75 6G基因多态性与Hcy水平及冠心病的关系进行探讨。　方法　 177例老年人为研究对象 ,其中 12 9例冠状动脉造影证实为冠心病患者 (冠心病组 ) ,4 8例冠状动脉造影完全正常 (对照组 )。荧光偏振免疫分析法测定Hcy水平 ,聚合酶链反应限制性片段长度多态性方法 (PCR RFLP)分析MTHFRA12 98C、MSA2 75 6G基因多态性。　结果　冠心病组血Hcy水平显著高于对照组〔(16 2± 8 6 )对 (12 7± 5 0 ) μmol/L ,P <0 0 1〕。MTHFRA12 98C基因多态性CC纯合子和AC杂合子血Hcy水平均显著低于AA野生型〔(9 1± 2 5 )、(13 5± 6 6 )对 (16 0± 8 3) μmol/L ,P <0 0 1〕 ,CC纯合子和AC杂合子间血Hcy水平差异无显著性 (P >0 0 5 ) ;MTHFR 12 98CC纯合子在冠心病组的分布频率显著低于对照组 (3 1%对 14 6 % ,P <0 0 5 )。MSA2 75 6G基因多态性GG +AG基因型血Hcy水平显著低于AA野生型〔(12 8± 6 5 )对 (15 6±8 1) μmol/L ,P <0 0 5〕 ,MS 2 75 6GG +AG基因型在冠心病组的分布频率显著低于对照组 (9 3%对2 0 8% ,P <0 0 5 )。　结论　本研究入选的老年人群中 ,冠心病

引用

页码：15 / 18

页数：4

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