药物性肝损伤的发病机制

被引：15

作者：

傅青春

吴银霞

机构：

[1] 南京军区上海临床肝病研究中心

来源：

医学与哲学(B) | 2013年 / 34卷 / 10期

关键词：

药物性肝损伤; 发病机制; 肝毒性; 特异质性肝损伤;

D O I：

暂无

中图分类号：

R595.3 [药源性疾病];

学科分类号：

100201 [内科学];

摘要：

药物性肝损伤(DILI)可分为直接肝毒性和特异质性肝损伤(IDILI)。IDILI发生率较低,个体发病存在易感因素,在动物模型中很难复制。同时,IDILI缺乏可靠的临床诊断标准,使其发病机制的研究受到限制。近年来关于IDILI的发病机制,主要在遗传易感性、代谢途径、宿主免疫、线粒体毒性和胆道损伤等方面取得进展,各种发病机制的深入研究和相互关系的阐明,或将揭示IDILI的真正致病机制。

引用

页码：14 / 16

页数：3

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