降钙素原在判断脓毒症的病情严重程度和预后中的临床价值

被引：9

作者：

陈璐

机构：

[1] 金华市中心医院检验科

来源：

中国卫生检验杂志 | 2019年 / 29卷 / 01期

关键词：

降钙素原; C-反应蛋白; APACHEⅡ评分; 危险因素; 预后;

D O I：

暂无

中图分类号：

R459.7 [急症、急救处理];

学科分类号：

100231 [临床病理学];

摘要：

目的探讨降钙素原在脓毒症患者病情严重程度评估和预后预测的临床价值。方法选取2013年1月-2017年12月在本院收治的脓毒症患者108例,分析其入院后PCT、CRP和APACHEⅡ评分,二元Logistic回归分析脓毒症患者预后危险因素。结果脓毒症患者的病情严重程度增加,PCT、CRP和APACHEⅡ评分逐渐增高。单因素分析和Logistic回归分析显示,PCT、CRP和APACHEⅡ评分是脓毒症患者死亡的危险因素。以ROC曲线下面积计算灵敏度及特异度,PCT以12. 92 ng/ml为截断值时,其灵敏度和特异度分别为81. 25%和77. 63%,CRP以39. 90 mg/L为截断值时,其灵敏度和特异度分别为75. 00%和65. 79%,APACHEⅡ评分以30. 64分为截断值时,其灵敏度和特异度分别为71. 88%和78. 95%,PCT预测价值优于CRP和APACHEⅡ评分。结论脓毒症患者的PCT水平与疾病严重程度呈正相关,是脓毒症患者死亡危险因素,且可以用来作为判断预后的血清学指标。

引用

页码：89 / 91

页数：3

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