标准化屋尘螨变应原制剂治疗儿童变应性哮喘68例

被引：14

作者：

王模奎

黄英

刘恩梅

戴继宏

陈坤华

蒋永惠

李素碧

机构：

[1] 重庆医科大学附属儿童医院呼吸科

来源：

中国新药与临床杂志 | 2006年 / 12期

关键词：

儿童; 哮喘; 免疫疗法; 标准化屋尘螨变应原制剂;

D O I：

暂无

中图分类号：

R725.6 [小儿呼吸系及胸部疾病];

学科分类号：

摘要：

目的:观察标准化屋尘螨变应原制剂治疗儿童变应性哮喘前后的临床疗效、肺功能与不良反应。方法:68例轻-中度儿童哮喘给予标准化屋尘螨变应原制剂治疗共25 wk。治疗前后监测肺功能,每日晨、晚间PEF,日间、夜间症状和药物评分。记录每次注射后的不良反应。结果:治疗前后FEV1,PEF占预计值的百分比分别为(96±s 24,113±16),(92±23,116±16)。0～12 wk和13～25 wk的平均日间、夜间症状和药物评分分别为(0．13±0．10,0．06±0．06),(0．06±0．07,0．02±0．04),(0．507±0．023, 0．48±0．05)分。差异均有显著意义(P<0．05)。每日晨、晚间PEF变异率从wk 13起即有变小趋势,但较0～12 wk时无显著差异(P>0．05)。未发生严重不良事件。结论:标准化屋尘螨变应原制剂治疗儿童变应性哮喘25 wk能显著减轻病人的症状、减少用药量和改善肺通气功能,可安全用于治疗儿童变应性哮喘。

引用

页码：935 / 938

页数：4

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