丹参酮ⅡA磺酸钠对烧伤植皮创面愈合及瘢痕形成的影响

被引：13

作者：

刘嘉楠 ^{[1
]}

何放 ^{[1
]}

钱明元 ^{[2
]}

郑小鹏 ^{[1
]}

罗鹏飞 ^{[1
]}

王亮 ^{[1
]}

程大胜 ^{[1
]}

唐洪泰 ^{[1
]}

常菲 ^{[1
]}

路卫 ^{[1
]}

机构：

[1] 第二军医大学长海医院全军烧伤中心

[2] 张家港市第一人民医院烧伤整形科

来源：

现代生物医学进展 | 2016年 / 16卷 / 07期

基金：

上海市自然科学基金;

关键词：

丹参酮ⅡA磺酸钠注射液; 植皮; 瘢痕;

D O I：

10.13241/j.cnki.pmb.2016.07.024

中图分类号：

R644 [烧伤及烫伤（灼伤）];

学科分类号：

100227 [皮肤病学];

摘要：

目的:探讨丹参酮IIA磺酸钠注射液对烧伤患者植皮创面愈合及瘢痕形成情况的影响。方法:选取2014年3月至2014年12月我院收治的烧伤植皮患者62例,根据临床用药分为试验组(使用丹参酮IIA磺酸钠注射组)与对照组(未使用丹参酮IIA磺酸钠注射液)。比较两组创面愈合情况,术后植皮成活率及愈合后瘢痕形成情况。结果:1经治疗,两组创面均愈合,试验组患者植皮成活率为(97.12±1.89)%,高于对照组(89.96±1.86)%,差异具有统计学意义(P<0.01);试验组愈合时间较对照组短,试验组创面愈合时间为10.1±1.9天,对照组为14.3±2.3天,两组比较差异具有统计学意义(P<0.001);瘢痕形成评价试验组均优于对照组,差异具有统计学意义,其中血肿面积(1.50±0.03 vs.3.04±0.08,P<0.01)、畸形率[2(6.45)vs.8(25.81),P<0.05]、感染率[2(6.45)vs.9(29.03),P<0.05]。结论:丹参酮IIA磺酸钠注射液对于烧伤植皮创面的患者,能够提高植皮成活率,促进创面愈合,减轻瘢痕形成,改善创面愈合质量。

引用

页码：1306 / 1308

页数：3

共 14 条

[1]

Up-to-date approach to manage keloids and hypertrophic scars: A useful guide [J].

Arno, Anna I. ;

Gauglitz, Gerd G. ;

Barret, Juan P. ;

Jeschke, Marc G. .

BURNS, 2014, 40 (07) :1255-1266

[2]

Effects of sodium tanshinone IIA sulfonate against Marek's disease virus in experimentally infected chickens.[J].Jin-qiang Zhang;Yao-liang Gu;Cai-hong Wu;Hai-li Ma;Jun-ping He;Yuan-sheng Bai;Hong-quan Li.International Journal of Biological Macromolecules.2013,

[3]

Sodium Tanshinone IIA Sulfonate Inhibits Canonical Transient Receptor Potential Expression in Pulmonary Arterial Smooth Muscle from Pulmonary Hypertensive Rats [J].

Wang, Jian ;

Jiang, Qian ;

Wan, Limei ;

Yang, Kai ;

Zhang, Yi ;

Chen, Yuqin ;

Wang, Elizabeth ;

Lai, Ning ;

Zhao, Lei ;

Jiang, Hua ;

Sun, Yueqian ;

Zhong, Nanshan ;

Ran, Pixin ;

Lu, Wenju .

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 2013, 48 (01) :125-134

[4]

Cardiovascular actions and therapeutic potential of tanshinone IIA.[J].Si Gao;Zhiping Liu;Hong Li;Peter J. Little;Peiqing Liu;Suowen Xu.Atherosclerosis.2011, 1

[5]

Tanshinone IIA Attenuates Peritoneal Fibrosis through Inhibition of Fibrogenic Growth Factors Expression in Peritoneum in a Peritoneal Dialysis Rat Model [J].

Jiang Chunming ;

Zhang Miao ;

Sun Cheng ;

Tao Nana ;

Zhu Wei ;

Cao Dongwei ;

Feng Yuan .

RENAL FAILURE, 2011, 33 (03) :355-362

[6]

Direct Vasorelaxation by a Novel Phytoestrogen Tanshinone IIA Is Mediated by Nongenomic Action of Estrogen Receptor Through Endothelial Nitric Oxide Synthase Activation and Calcium Mobilization [J].

Fan, Guanwei ;

Zhu, Yan ;

Guo, Hao ;

Wang, Xiaoying ;

Wang, Hong ;

Gao, Xiumei .

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 2011, 57 (03) :340-347

[7]

Effects of TGF-β1 on the proliferation and differentiation of human periodontal ligament cells and a human periodontal ligament stem/progenitor cell line [J].

Fujii, Shinsuke ;

Maeda, Hidefumi ;

Tomokiyo, Atsushi ;

Monnouchi, Satoshi ;

Hori, Kiyomi ;

Wada, Naohisa ;

Akamine, Akifumi .

CELL AND TISSUE RESEARCH, 2010, 342 (02) :233-242

[8]

Tanshinone II-A attenuates cardiac fibrosis and modulates collagen metabolism in rats with renovascular hypertension [J].

Fang, Jian ;

Xu, Suo-Wen ;

Wang, Ping ;

Tang, Fu-Tian ;

Zhou, Si-Gui ;

Gao, Jie ;

Chen, Jian-Wen ;

Huang, He-Qing ;

Liu, Pei-Qing .

PHYTOMEDICINE, 2010, 18 (01) :58-64

[9]

Molecular dissection of abnormal wound healing processes resulting in keloid disease [J].

Shih, Barbara ;

Garside, Elloise ;

McGrouther, Duncan Angus ;

Bayat, Ardeshir .

WOUND REPAIR AND REGENERATION, 2010, 18 (02) :139-153

[10]

Tanshinone IIA inhibits constitutive STAT3 activation; suppresses proliferation; and induces apoptosis in rat C6 glioma cells.[J].Chao Tang;Hong-li Xue;Hai-bo Huang;Xiao-gang Wang.Neuroscience Letters.2009, 2

← 1 2 →