螺旋藻多糖对小鼠和犬造血系统的化学和放射防护作用(英文)

被引：10

作者：

张洪泉

林安平

孙云

邓杨梅

机构：

[1] 扬州大学医药研究所,扬州大学医药研究所,扬州大学医药研究所,扬州大学医药研究所扬州,中国,扬州,中国,扬州,中国,扬州,中国

来源：

Acta Pharmacologica Sinica | 2001年 / 12期

关键词：

螺旋藻; 多糖类; 骨髓; γ射线; 辐射防护剂; 血红蛋白类; 红细胞计数; 白细胞计数;

D O I：

暂无

中图分类号：

R285 [中药药理学];

学科分类号：

1008 ;

摘要：

目的:研究螺旋藻多糖（PSp）对环磷酰胺和60CO-γ射线所致小白鼠和犬造血系统抑制的影响。方法:腹腔注射环磷酰胺以及用60CO-γ射线照射分别诱发小鼠和犬的骨髓损伤。全血细胞计数和骨髓有核细胞计数。用紫外分光光度计检测骨髓DNA的含量。结果:环磷酰胺和60CO-γ射线分别造成小鼠和犬骨髓造血系统抑制性损伤。PSp 30,60mg/kg能升高小鼠全血白细胞数和骨髓有核细胞数以及DNA含量;PSp 12mg/kg能使犬骨髓有核细胞数,以及外周血红细胞、白细胞及血红蛋白水平得以回升（P<0.01）,其疗效优于盐酸小壁胺。结论:PSp对造血系统有化学保护和放射保护作用。

引用

页码：67 / 70

页数：4

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