癌症预防中的Keap1-Nrf2-ARE通路

被引：14

作者：

刘晓平

机构：

[1] 皖南医学院药学系

来源：

中国临床药理学与治疗学 | 2008年 / 06期

关键词：

癌症; 预防; Keap1-Nrf2-ARE信号通路;

D O I：

暂无

中图分类号：

R730.1 [肿瘤的预防与控制];

学科分类号：

100214 ;

摘要：

癌症的治疗至今仍未取得重大进展,因此做好癌症的预防工作就尤为关键。目前有很多自然物质(如从植物中提取的抗氧化剂)或化学合成物质(如添加在食品中的抗氧化剂)被用来预防癌症。最近发现,有些癌症预防物是通过诱导二相抗氧化酶来清除体内的致癌物质或其它毒物,而且这种诱导作用是通过Keap1-Nrf2-ARE信号通路。因此,对这一通路的了解有利于拓展癌症的研究及预防。

引用

页码：716 / 720

页数：5

共 8 条

[1] Extract of Ginkgo biloba induces phase 2 genes through Keap1-Nrf2-ARE signaling pathway [J].

Liu, Xiao-Ping ;

Goldring, Christopher E. P. ;

Copple, Ian M. ;

Wang, Hai-Yi ;

Wei, Wei ;

Kitteringham, Neil R. ;

Park, B. Kevin .

LIFE SCIENCES, 2007, 80 (17) :1586-1591

[2] Action of Nrf2 and Keap1 in ARE-mediated NQO1 expression by quercetin [J].

Tanigawa, Shunsuke ;

Fujii, Makoto ;

Hou, De-Xing .

FREE RADICAL BIOLOGY AND MEDICINE, 2007, 42 (11) :1690-1703

[3]

Cell Survival Responses to Environmental Stresses Via the Keap1-Nrf2-ARE Pathway[J] . Thomas W. Kensler,Nobunao Wakabayashi,Shyam Biswal.Annual Review of Pharmacology and Toxicology . 2007 (0)

[4]

Cytochromes P450 and metabolism of xenobiotics[J] . P. Anzenbacher,E. Anzenbacherová.Cellular and Molecular Life Sciences . 2001 (5)

[5] Regulatory mechanisms of cellular response to oxidative stress [J].

Itoh, K ;

Ishii, T ;

Wakabayashi, N ;

Yamamoto, M .

FREE RADICAL RESEARCH, 1999, 31 (04) :319-324

[6] An Nrf2 small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements [J].

Itoh, K ;

Chiba, T ;

Takahashi, S ;

Ishii, T ;

Igarashi, K ;

Katoh, Y ;

Oyake, T ;

Hayashi, N ;

Satoh, K ;

Hatayama, I ;

Yamamoto, M ;

Nabeshima, Y .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1997, 236 (02) :313-322

[7]

Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain. Itoh K, Wakabayashi N, Katoh Y, et al. Genes and Development . 1999

[8]

Enhanced expression of the transcription factor Nrf2 by cancer chemopreventive agents: role of antioxidant response element-like sequences in the nrf2 promoter. Kwak MK,Itoh K,Yamamoto M, et al. Molecular and Cellular Biology . 2002

← 1 →