氧自由基对肌皮瓣缺血再灌注的损伤及维生素C对损伤的防护

被引：9

作者：

毛运春

吴念

孙伯华

赵萍

机构：

[1] 中国医学科学院中国协和医科大学整形外科医院

[2] 中国医学科学院中国协和医科大学整形外科医院北京

[3] 北京

来源：

中华整形烧伤外科杂志 | 1998年 / 02期

关键词：

氧自由基; 缺血再灌注损伤; 超氧化物歧化酶; 丙二醛;

D O I：

暂无

中图分类号：

R622 [整形手术学];

学科分类号：

1002 ; 100210 ;

摘要：

目的探讨氧自由基对肌皮瓣的损伤及机体对自由基的清除过程,以及维生素C等抗氧化剂的作用规律。方法以大白兔为动物模型,形成缺血再灌注肌皮辦,动态测定缺血、再灌注不同时间内超氧化物歧化酶（SOD）、谷胱甘肽过氧化物酶（GSH-Px）、丙二醛（MDA）变化及静脉滴注维生素C对其影响。结果缺血再灌注损伤在缺血期已经开始,随着缺血时间的延长而加重,再灌注时损伤进一步加重,超氧阴离子自由基（O2-）、羟自由基（·OH）于再灌注后不久即被清除,脂质过氧化物的清除需要较长时间,维生素C对缺血再灌注损伤有一定的保护作用。结论在组织移植中应争取最短的缺血、最快的再灌注,应用药物抗氧化时应于缺血前用药并持续至再灌注后数天。

引用

页码：118 / 121

页数：4

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