不同剂量阿托伐他汀对老年急性冠状动脉综合征患者hs-CRP、Hcy水平的影响及安全性观察

被引：5

作者：

陈杰

孙立勤

于春艳

机构：

[1] 宁波市第七医院心内科

来源：

浙江医学 | 2014年 / 36卷 / 16期

关键词：

阿托伐他汀; 急性冠状动脉综合征; 超敏C反应蛋白; 同型半胱氨酸; 老年;

D O I：

暂无

中图分类号：

R541.4 [冠状动脉（粥样）硬化性心脏病（冠心病）];

学科分类号：

100201 [内科学];

摘要：

目的比较不同剂量阿托伐他汀对老年急性冠状动脉综合征(ACS)患者超敏C反应蛋白(hs-CRP)、同型半胱氨酸(Hcy)水平的影响及安全性。方法选择老年ACS患者162例,分为A组(阿托伐他汀20mg/d)、B组(阿托伐他汀40mg/d)、C组(阿托伐他汀80mg/d),各54例,所有患者分别于入院后24 h内和服药后4周、12周采血测定hs-CRP、Hcy、TG、TC、HDL-C、LDL-C。入院后24 h内和服药后12周清晨空腹采静脉血,测定ALT、肌酸激酶(CK)、血肌酐(SCr)水平。结果 3组患者治疗后TC、LDL-C、TG水平均较治疗前下降(P<0.05或0.01),B、C组患者治疗后第12周HDL-C水平较治疗前升高(P<0.05)。与A组比较,B组在治疗第4周时LDL-C水平降低,第12周时TC、LDL-C水平降低(P<0.05),C组在治疗第4、12周时TC、LDL-C、TG水平均降低(P<0.05或0.01),治疗第1 2周时HDL-C水平升高(P<0.05)。治疗后3组患者hs-CRP、Hcy水平均较治疗前下降(P<0.05或0.01),与A组比较,B、C组在治疗第4、12周时hs-CRP、Hcy水平均降低(p<0.05或0.01)。治疗后3组患者ALT、CK、SCr水平均未见明显升高(均P>0.05),与A组治疗后第12周比较,B、C组ALT、CK、SCr水平差异均无统计学意义(均P>0.05)。结论在老年ACS患者中,80mg/d阿托伐他汀治疗是有效且安全的。

引用

页码：1398 / 1401

页数：4

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