膝骨关节炎中天然免疫和TLR/NF-κB信号通路的研究进展

被引：28

作者：

陈金伟

吕杰

俞银贤

马金忠

机构：

[1] 上海交通大学附属第一人民医院骨科

来源：

中华临床医师杂志(电子版) | 2013年 / 7卷 / 24期

关键词：

骨关节炎; 补体系统蛋白质类; 细胞因子类; Toll样受体; NF-κB;

D O I：

暂无

中图分类号：

R684.3 [关节炎];

学科分类号：

100220 [骨科学];

摘要：

膝骨关节炎(OA),是由多种因素引起关节软骨纤维化、破损、降解、脱失而导致的关节退行性疾病。目前,有越来越多的研究表明,骨关节炎的发生、进展有toll样受体(TLR)介导的天然免疫系统的参与,其中TLR/NF-κB信号通路扮演了重要角色。一般认为,遗传、代谢或机械因素造成关节软骨的初始伤害,导致软骨释放特定的自身抗原触发自身免疫反应。包括T细胞、B细胞和巨噬细胞在内的免疫细胞渗透到关节组织,释放各种细胞因子和趋化因子,例如基质金属蛋白酶(MMPs)和前列腺素E2(PGE2)释放,补体系统被激活,导致软骨降解,关节软骨进一步被破坏。本文回顾在OA发病机制中的天然免疫系统和TLR/NF-κB信号通路的作用。

引用

页码：11602 / 11606

页数：5

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