肿瘤坏死因子A-308位点基因多态性与成人重度牙周炎的关系

被引：13

作者：

钱伟

章锦才

张蕴惠

机构：

[1] 四川大学华西口腔医学院牙周科

来源：

中华口腔医学杂志 | 2002年 / 02期

关键词：

肿瘤坏死因子; 基因; 牙周炎; 聚合酶链反应;

D O I：

暂无

中图分类号：

R781.42 [];

学科分类号：

摘要：

目的　探讨肿瘤坏死因子 (tumornecrosisfactor,TNF)A 30 8位点基因多态性与汉族成人重度牙周炎易感性的关系。方法　收集 6 5例成人重度牙周炎患者和 96名健康对照者的颊粘膜拭子 ,采用Chelex 10 0法提取DNA ,PCR限制性内切酶片段长度多态性 (PCR RFLP)法检测基因多态性 ,用计算机软件统计分析患者和对照组间基因型分布的差异。结果　TNFA 30 8位点等位基因 1和 2的分布在患者和对照组间差异有高度显著性 (P <0 0 0 1) ,患者中“1/ 1”基因型明显占多数 ,危险分析显示等位基因“1/ 1”纯合子个体患重度牙周炎的几率比“1/ 2”、“2 / 2”基因型个体高 3 6 4倍。结论　TNFA 30 8等位基因 1/ 1纯合子基因型可能是重度牙周炎的易感因素。

引用

页码：49 / 51

页数：3

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